CAJ | 학술논문

压力因素致使交感神经系统持续激活是原发性高血压发生发展的独立危险因素.肾上腺激素生物合成通路是交感神经系统的重要组成部分,该通路由激素、神经递质、受体及各种合成酶和转化酶组成.在本文中,我们将系统地阐释肾上腺激素生物合成通路相关基因与压力因素相互作用形成高血压的机制及研究进展.
압력인소치사교감신경계통지속격활시원발성고혈압발생발전적독립위험인소.신상선격소생물합성통로시교감신경계통적중요조성부분,해통로유격소、신경체질、수체급각충합성매화전화매조성.재본문중,아문장계통지천석신상선격소생물합성통로상관기인여압력인소상호작용형성고혈압적궤제급연구진전.
Sustained activation of sympathetic nervous system in response to stimulation of a wide variety of stress factors is an independent risk factor for the development of essential hypertension.Adrenal hormone biosynthesis pathway as an important part of the sympathetic nervous system consists of hormones,neurotransmitters,receptors,and a variety of synthases and invertases.In this article,we have systematically reviewed research progresses made in elucidating the interactions between genes of the adrenal hormone biosynthesis pathway and stress factors in the pathogenesis of essential hypertension.