CAJ | 학술논문

目的探讨使用本地区孕中期产前筛查中位数进行产前筛查效果评价的方法和截断值确定.方法应用受试者工作特征(receiver operating characteristic,ROC)曲线分析方法,对使用新模型计算的本地区中位数和2T软件内置中位数进行孕中期产前筛查结果比较,通过检出率和假阳性率等相关数据列表分析,确定截断值.结果使用ROC曲线分析,可以明确判断出两套中位数筛查效果的差异,并根据假阳性率和检出率确定本地区实验室截断值.结论 ROC曲线是使用新的中位数进行产前筛查效果评价的一种方法,并能检验实验室建立的截断值是否合理,从而确立新的截断值.
목적 탐토사용본지구잉중기산전사사중위수진행산전사사효과평개적방법화절단치학정.방법 응용수시자공작특정(receiver operating characteristic,ROC)곡선분석방법,대사용신모형계산적본지구중위수화2T연건내치중위수진행잉중기산전사사결과비교,통과검출솔화가양성솔등상관수거렬표분석,학정절단치.결과 사용ROC곡선분석,가이명학판단출량투중위수사사효과적차이,병근거가양성솔화검출솔학정본지구실험실절단치.결론 ROC곡선시사용신적중위수진행산전사사효과평개적일충방법,병능검험실험실건립적절단치시부합리,종이학립신적절단치.
Objective To develop a method for evaluating the feasibility of prenatal screening using local median value and determining the cut-off value.Methods With receiver operating characteristic curve (ROC) analysis,results of second trimester prenatal screening calculated by a local median value in a new model and the built-in median value in 2T software were compared.The cut-off value was set by serial analysis of true and false positive rates and other relevant data.Results The ROC curve has accurately estimated the difference in the screening efficacy between a local median value and that embedded in the 2T model,and established a reasonable cut-off value for the laboratory based on false positive rate and detection rate.Conclusion The method of ROC curve can be used to evaluate the performance of local median value in prenatal screening and to test the rationality of cut-off value established in the laboratory.As the result,a better cut-off value may be derived.