中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2013年
2期
129-131
,共3页
池闯%何志锋%刘瑜%林晓铭%孙成超
池闖%何誌鋒%劉瑜%林曉銘%孫成超
지틈%하지봉%류유%림효명%손성초
癌,非小细胞肺%生物钟基因Per2%免疫组织化学
癌,非小細胞肺%生物鐘基因Per2%免疫組織化學
암,비소세포폐%생물종기인Per2%면역조직화학
Carcinoma,non-small cell lung%Circadian gene Per2%Immunohistochemistry
目的 研究生物钟基因Per2在非小细胞肺癌(NSCLC)中的表达及其临床意义.方法 采用免疫组织化学染色法检测60例NSCLC组织和20例正常肺组织中Per2蛋白的表达,分析其表达与NSCLC临床病理特征的关系.结果 NSCLC和正常肺组织中Per2蛋白的阳性表达率分别为71.7％ (43/60)和95.0％ (19/20),差异有统计学意义(P＜0.05).Per2表达与NSCLC分化程度和TMN分期相关(P＜0.05).结论 Per2在NSCLC组织中表达降低,Per2在NSCLC的发生和发展中起重要作用.
目的 研究生物鐘基因Per2在非小細胞肺癌(NSCLC)中的錶達及其臨床意義.方法 採用免疫組織化學染色法檢測60例NSCLC組織和20例正常肺組織中Per2蛋白的錶達,分析其錶達與NSCLC臨床病理特徵的關繫.結果 NSCLC和正常肺組織中Per2蛋白的暘性錶達率分彆為71.7％ (43/60)和95.0％ (19/20),差異有統計學意義(P＜0.05).Per2錶達與NSCLC分化程度和TMN分期相關(P＜0.05).結論 Per2在NSCLC組織中錶達降低,Per2在NSCLC的髮生和髮展中起重要作用.
목적 연구생물종기인Per2재비소세포폐암(NSCLC)중적표체급기림상의의.방법 채용면역조직화학염색법검측60례NSCLC조직화20례정상폐조직중Per2단백적표체,분석기표체여NSCLC림상병리특정적관계.결과 NSCLC화정상폐조직중Per2단백적양성표체솔분별위71.7％ (43/60)화95.0％ (19/20),차이유통계학의의(P＜0.05).Per2표체여NSCLC분화정도화TMN분기상관(P＜0.05).결론 Per2재NSCLC조직중표체강저,Per2재NSCLC적발생화발전중기중요작용.
Objective To detect the expression of Per2 in non-small cell lung cancer (NSCLC),and analyze its clinical significance.Methods The expression of Per2 was determined in 60 NSCLC and 20 normal lung tissues by immunohistochemical assay,and the relationship between Per2 expression and clinicopathological features was analyzed.Results The positive expression rates of Per2 in NSCLC and normal lung tissues were 71.7％ and 95.0％,respectively (P ＜ 0.05).The expression of Per2 in NSCLC was correlated with pathological differentiation and TNM stage (P ＜ 0.05).Conclusion The expression of Per2 in NSCLC is decreased.The negative expression of Per2 may contribute to the development and invasion in NSCLC.
