中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2013年
8期
604-607
,共4页
郭曦%刘天舒%余一祎%周宇红%陈勇%庄荣源%崔越宏
郭晞%劉天舒%餘一祎%週宇紅%陳勇%莊榮源%崔越宏
곽희%류천서%여일의%주우홍%진용%장영원%최월굉
结直肠肿瘤,肿瘤转移%药物疗法%贝伐珠单抗%治疗结果%药物毒性
結直腸腫瘤,腫瘤轉移%藥物療法%貝伐珠單抗%治療結果%藥物毒性
결직장종류,종류전이%약물요법%패벌주단항%치료결과%약물독성
Colorectal neoplasms,neoplasms metastasis%Drug therapy%Bevacizumab%Treatment outcome%Drug toxicity
目的 观察贝伐珠单抗与化疗药物联合治疗转移性结直肠癌的近期疗效和安全性.方法 应用贝伐珠单抗联合5-氟尿嘧啶类、奥沙利铂、伊立替康为基础的化疗方案治疗转移性结直肠癌患者77例,观察其临床疗效和贝伐珠单抗相关的不良反应.至少2个周期贝伐珠单抗治疗后评估疗效,每周期治疗后记录不良反应.结果 77例患者平均接受贝伐珠单抗联合化疗治疗5.2个周期,有64例患者可评估疗效,其中部分缓解(PR)12例,疾病稳定(SD)36例,疾病进展(PD) 16例,有效率为18.8% (12/64),疾病控制率为75.0% (48/64).一线治疗患者27例,有效率为37.0%(10/27),疾病控制率为85.2% (23/27).4例患者肝转移灶由潜在可切除变成可切除病灶,并成功接受了肝转移灶的R0切除术.二线治疗患者25例,有效率为8.0% (2/25),疾病控制率为76.0%(19/25).所有患者均可进行不良反应评估,与贝伐珠单抗治疗相关的不良反应主要为高血压、蛋白尿和出血等,绝大多数为1~2级.结论 贝伐珠单抗联合化疗治疗转移性结直肠癌的一线治疗效果较好,疾病控制率高;二线及以上治疗的疗效欠佳,但疾病控制率尚可.与贝伐珠单抗治疗相关的不良反应较轻,患者的耐受性较好.
目的 觀察貝伐珠單抗與化療藥物聯閤治療轉移性結直腸癌的近期療效和安全性.方法 應用貝伐珠單抗聯閤5-氟尿嘧啶類、奧沙利鉑、伊立替康為基礎的化療方案治療轉移性結直腸癌患者77例,觀察其臨床療效和貝伐珠單抗相關的不良反應.至少2箇週期貝伐珠單抗治療後評估療效,每週期治療後記錄不良反應.結果 77例患者平均接受貝伐珠單抗聯閤化療治療5.2箇週期,有64例患者可評估療效,其中部分緩解(PR)12例,疾病穩定(SD)36例,疾病進展(PD) 16例,有效率為18.8% (12/64),疾病控製率為75.0% (48/64).一線治療患者27例,有效率為37.0%(10/27),疾病控製率為85.2% (23/27).4例患者肝轉移竈由潛在可切除變成可切除病竈,併成功接受瞭肝轉移竈的R0切除術.二線治療患者25例,有效率為8.0% (2/25),疾病控製率為76.0%(19/25).所有患者均可進行不良反應評估,與貝伐珠單抗治療相關的不良反應主要為高血壓、蛋白尿和齣血等,絕大多數為1~2級.結論 貝伐珠單抗聯閤化療治療轉移性結直腸癌的一線治療效果較好,疾病控製率高;二線及以上治療的療效欠佳,但疾病控製率尚可.與貝伐珠單抗治療相關的不良反應較輕,患者的耐受性較好.
목적 관찰패벌주단항여화료약물연합치료전이성결직장암적근기료효화안전성.방법 응용패벌주단항연합5-불뇨밀정류、오사리박、이립체강위기출적화료방안치료전이성결직장암환자77례,관찰기림상료효화패벌주단항상관적불량반응.지소2개주기패벌주단항치료후평고료효,매주기치료후기록불량반응.결과 77례환자평균접수패벌주단항연합화료치료5.2개주기,유64례환자가평고료효,기중부분완해(PR)12례,질병은정(SD)36례,질병진전(PD) 16례,유효솔위18.8% (12/64),질병공제솔위75.0% (48/64).일선치료환자27례,유효솔위37.0%(10/27),질병공제솔위85.2% (23/27).4례환자간전이조유잠재가절제변성가절제병조,병성공접수료간전이조적R0절제술.이선치료환자25례,유효솔위8.0% (2/25),질병공제솔위76.0%(19/25).소유환자균가진행불량반응평고,여패벌주단항치료상관적불량반응주요위고혈압、단백뇨화출혈등,절대다수위1~2급.결론 패벌주단항연합화료치료전이성결직장암적일선치료효과교호,질병공제솔고;이선급이상치료적료효흠가,단질병공제솔상가.여패벌주단항치료상관적불량반응교경,환자적내수성교호.
Objective To assess the efficacy and safety of bevacizumab (BEV) plus chemotherapeutic agents in the treatment of metastatic colorectal cancer (mCRC).Methods Seventy-seven mCRC patients received BEV plus 5-Fu type,oxaliplatin or irinotecan-based chemotherapy.The clinical efficacy and bevacizumab-related adverse reactions were observed.The efficacy assessment was conducted after at least 2 cycles of BEV therapy.The adverse reactions were recorded in each therapy cycle.Among the 77 cases,64 patients had finished the efficacy assessment.The adverse reactions in all patients were assessed.Results The overall response rate (ORR) of BEV plus chemotherapy regimen was 18.75% (12/64),and the disease control rate (DCR) was 75.0% (48/64).In 27 patients who received the regimen as first-line treatment,the ORR reached 37.0% (10/27),while the DCR was 85.2%.Four patients with potentially resectable lesions became resectable after the regimen and received RO resection of the liver metastases successfully.Twenty-five patients who received the regimen as second line therapy had poor result with ORR 8.0% and DCR 76.0%.Hypertension was observed in 12 cases,with 8 cases of grade 1,3 cases of grade 2,1 case of grade 3.Various bleedings occurred in 24/77 cases (31.2%),all were of grade 1-2,including 17 cases of epistaxis,grade 1 hemorrhoid bleeding in one case,hematuria in 3 case (2 of grade 1,1 of grade 2),GI bleeding in 2 cases,hemoptysis in 1 case (grade 2),and proteinuria in 4 cases (grade 1).Intestinal perforation occurred in 1 case (0.3%).In two patients who had incomplete intestinal obstruction history appeared exacerbated intestinal obstruction symptoms after the application of BEV plus CPT11 regimen.Conclusions BEV plus chemotherapy regimen as first-line treatment can improve the ORR and DCR of mCRC patients.When it was used as second-or later-line therapy,it may display satisfied DCR,although with a poor efficacy.The bevacizumab-related toxicity is mild and can be well tolerated.