CAJ | 학술논문

目的探讨人群中尿镉水平与乳腺癌临床病理特征之间的关系.方法 2009年10月至2010年7月间,对240例乳腺癌患者进行临床资料和尿液标本的收集,采用电感耦合等离子体质谱仪检测尿镉水平.采用x2检验和Wilcoxon秩和检验分析尿镉水平与乳腺癌病理特征之间的关系.结果 240例乳腺癌患者尿镉浓度的中位数、第25百分位数(P25)和第75百分位数(P75)分别为1.99μg/g、1.32μg/g和2.88 μg/g.尿镉高水平组和中低水平组患者的人表皮生长因子受体2(HER-2)阳性率分别为28.2％和16.5％,差异有统计学意义(P =0.042).尿镉高水平组和中低水平组患者的淋巴结和(或)远处转移率分别为47.2％和32.0％,差异有统计学意义(P=0.028).与尿镉中低水平组比较,尿镉高水平组患者的TNM分期较晚(P =0.017).采用非条件Logistic回归模型校正年龄后,结果依然显示尿镉水平与HER-2状态、淋巴结和(或)远处转移情况及TNM分期有关(均P＜0.05).结论尿镉水平与乳腺癌患者的HER-2状态、淋巴结和(或)远处转移情况及TNM分期有关；镉可能导致侵袭力强和恶性程度高的人类乳腺癌.
목적 탐토인군중뇨력수평여유선암림상병리특정지간적관계.방법 2009년10월지2010년7월간,대240례유선암환자진행림상자료화뇨액표본적수집,채용전감우합등리자체질보의검측뇨력수평.채용x2검험화Wilcoxon질화검험분석뇨력수평여유선암병리특정지간적관계.결과 240례유선암환자뇨력농도적중위수、제25백분위수(P25)화제75백분위수(P75)분별위1.99μg/g、1.32μg/g화2.88 μg/g.뇨력고수평조화중저수평조환자적인표피생장인자수체2(HER-2)양성솔분별위28.2％화16.5％,차이유통계학의의(P =0.042).뇨력고수평조화중저수평조환자적림파결화(혹)원처전이솔분별위47.2％화32.0％,차이유통계학의의(P=0.028).여뇨력중저수평조비교,뇨력고수평조환자적TNM분기교만(P =0.017).채용비조건Logistic회귀모형교정년령후,결과의연현시뇨력수평여HER-2상태、림파결화(혹)원처전이정황급TNM분기유관(균P＜0.05).결론 뇨력수평여유선암환자적HER-2상태、림파결화(혹)원처전이정황급TNM분기유관；력가능도치침습력강화악성정도고적인류유선암.
Objective The aim of this study was to investigate the association between urinary cadmium and clinicopathological characteristics of breast cancer.Methods The clinicopathological characteristics of 240 patients with breast cancer were obtained and urine specimens were collected from October 2009 to July 2010.The concentration of urinary cadmium was determined by inductively coupled plasma mass spectrometry (ICP-MS).x2 test and Wilcoxon rank sum test were used to analyze whether urinary cadmium is associated with clinicopathological characteristics of breast cancer.Results The median concentration of urine cadmium of 240 patients was 1.99 μg/g (25th percentile,1.32 μg/g; 75th percentile,2.88 μg/g).HER-2 positive rate,regional/distant metastasis rate,and advanced stage rate in patients with the highest tertile of cadmium concentration were significantly higher than those in the patients with second and lowest Cd tertiles (P =0.042,P =0.028 and P =0.017,respectively),and 28.2％ vs.16.5％ for HER-2 and 47.2％ vs.32.0％ for regional/distant metastasis,respectively.There were still significant associations between urinary cadmium levels and these clinicopathological parameters after being adjusted in age by unconditional logistic regression model,respectively (P ＜ 0.05).Conclusions The results of this study suggest that urinary cadmium levels are associated with the HER-2 status,regional/distant metastasis status and stages of breast cancer,respectively.Cadmium may induce highly aggressive breast cancer in humans.