中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2013年
9期
693-697
,共5页
胃肿瘤%胸腔积液,恶性%腹腔%预后
胃腫瘤%胸腔積液,噁性%腹腔%預後
위종류%흉강적액,악성%복강%예후
Stomach neoplasms%Pleural effusion,malignant%Abdominal cavity%Prognosis
目的 分析胃癌和胃食管结合部癌合并恶性胸腹腔积液患者的预后,并探讨其影响因素.方法 回顾性分析2001年1月至2010年12月中国医学科学院肿瘤医院收治的111例胃癌和胃食管结合部癌合并恶性胸腹腔积液患者的临床病理资料,比较不同临床病理特征患者的积液控制情况和预后.结果 111例患者中,治疗后积液消失12例(10.8％),减少36例(32.4％),稳定15例(13.5％),增多48例(43.2％),积液控制率为56.8％.女性、单纯腹腔积液、KPS评分≥80分、初诊合并积液、无肝转移和全身化疗有效的患者积液控制情况较好.111例患者的中位生存时间为6.0个月.单因素分析的结果显示,女性、KPS评分≥80分、初诊时合并积液、单纯腹腔积液、少量积液、无肝转移、接受全身化疗、积液控制、全身化疗有效、血红蛋白和白蛋水平正常、总胆红素、直接胆红素和间接胆红素水平正常的患者预后较好(均P ＜0.05).多因素分析的结果显示,有无肝转移和积液控制情况是影响胃癌和胃食管结合部癌合并恶性积液患者预后的独立因素(均P＜0.05).结论 女性、单纯腹腔积液、KPS评分≥80分、初诊合并积液、无肝转移和全身化疗有效的胃癌和胃食管结合部癌合并恶性积液患者积液控制情况较好,无肝转移和积液控制好的患者生存时间更长.
目的 分析胃癌和胃食管結閤部癌閤併噁性胸腹腔積液患者的預後,併探討其影響因素.方法 迴顧性分析2001年1月至2010年12月中國醫學科學院腫瘤醫院收治的111例胃癌和胃食管結閤部癌閤併噁性胸腹腔積液患者的臨床病理資料,比較不同臨床病理特徵患者的積液控製情況和預後.結果 111例患者中,治療後積液消失12例(10.8％),減少36例(32.4％),穩定15例(13.5％),增多48例(43.2％),積液控製率為56.8％.女性、單純腹腔積液、KPS評分≥80分、初診閤併積液、無肝轉移和全身化療有效的患者積液控製情況較好.111例患者的中位生存時間為6.0箇月.單因素分析的結果顯示,女性、KPS評分≥80分、初診時閤併積液、單純腹腔積液、少量積液、無肝轉移、接受全身化療、積液控製、全身化療有效、血紅蛋白和白蛋水平正常、總膽紅素、直接膽紅素和間接膽紅素水平正常的患者預後較好(均P ＜0.05).多因素分析的結果顯示,有無肝轉移和積液控製情況是影響胃癌和胃食管結閤部癌閤併噁性積液患者預後的獨立因素(均P＜0.05).結論 女性、單純腹腔積液、KPS評分≥80分、初診閤併積液、無肝轉移和全身化療有效的胃癌和胃食管結閤部癌閤併噁性積液患者積液控製情況較好,無肝轉移和積液控製好的患者生存時間更長.
목적 분석위암화위식관결합부암합병악성흉복강적액환자적예후,병탐토기영향인소.방법 회고성분석2001년1월지2010년12월중국의학과학원종류의원수치적111례위암화위식관결합부암합병악성흉복강적액환자적림상병리자료,비교불동림상병리특정환자적적액공제정황화예후.결과 111례환자중,치료후적액소실12례(10.8％),감소36례(32.4％),은정15례(13.5％),증다48례(43.2％),적액공제솔위56.8％.녀성、단순복강적액、KPS평분≥80분、초진합병적액、무간전이화전신화료유효적환자적액공제정황교호.111례환자적중위생존시간위6.0개월.단인소분석적결과현시,녀성、KPS평분≥80분、초진시합병적액、단순복강적액、소량적액、무간전이、접수전신화료、적액공제、전신화료유효、혈홍단백화백단수평정상、총담홍소、직접담홍소화간접담홍소수평정상적환자예후교호(균P ＜0.05).다인소분석적결과현시,유무간전이화적액공제정황시영향위암화위식관결합부암합병악성적액환자예후적독립인소(균P＜0.05).결론 녀성、단순복강적액、KPS평분≥80분、초진합병적액、무간전이화전신화료유효적위암화위식관결합부암합병악성적액환자적액공제정황교호,무간전이화적액공제호적환자생존시간경장.
Objective To explore the prognostic factors in patients with gastric cancer (GC) or adenocarcinoma of the esophagogastric junction (AEG) combined with malignant pleural and/or abdominal effusion.Methods Clinicopathological data of 111 GC or AEG patients with malignant pleural and/or abdominal effusion treated in our hospital from January 2001 to December 2010 were retrospectively analyzed.Results The median survival time for the whole group of 111 patients was 6 months.Effusion disappeared in 12 patients,was reduced in 36 cases,with no changes in 15 cases,and increased in 48 patients.The effusion control rate was 56.8％.Effusion was better controlled in female patients,with simple abdominal ascites,Karnovsky performance scores ≥ 80,with no liver metastases,effusion at initial diagnosis,and effective response to systemic chemotherapy.Univariate analysis showed that patients of female sex,Karnovsky performance scores ≥ 80,effusion present at initial diagnosis,simple abdominal ascites,minimal volume of effusion,absence of liver metastasis,control of effusion,initial treatment with effusions and effective response to systemic chemotherapy,normal hemoglobin,albumin,direct and indirect bilirubin levels showed better prognosis (all P ＜ 0.05).Multivariate analysis showed that liver metastases,control of effusions were independent prognostic factors in patients with gastric cancer and adenocarcinoma of the esophagogastric junction (all P ＜ 0.05).Conclusions Female patients,simple abdominal ascites,KPS scores ≥80,ascites at initial diagnosis,no liver metastases and effective systemic chemotherapy seem to have a better control of the malignant effusion.Patients with no liver metastases and effective control of effusion have a longer survival time.
