CAJ | 학술논문

目的探讨影响乳腺癌前哨淋巴结和非前哨淋巴结转移的相关因素.方法回顾性分析2010年7月至2011年8月收治的、行前哨淋巴活检的283例女性乳腺癌患者的临床资料.结果单因素分析结果显示,患者年龄、是否绝经、肿瘤大小、病理类型和脉管瘤栓均与前哨淋巴结转移(SLNM)有关(均P＜0.05)；年龄、恶性肿瘤家族史、绝经情况、局部切除术、示踪技术、前哨淋巴结阳性、肿瘤大小、病理类型、分化程度、雌激素受体(ER)阳性、孕激素受体阳性、人表皮生长因子受体2阳性数目、脉管瘤栓和Ki-67≥15％等均与非前哨淋巴结转移无关(均P＞0.05).Logistic回归分析结果显示,患者年龄、肿瘤大小和脉管瘤栓均与SLNM有关(均P＜0.05).结论患者年龄、肿瘤大小和脉管瘤栓是影响SLNM的独立因素,其中年龄是保护因素.而病理类型、病理分级和ER状态是否与SLNM有关存在争议.
목적 탐토영향유선암전초림파결화비전초림파결전이적상관인소.방법 회고성분석2010년7월지2011년8월수치적、행전초림파활검적283례녀성유선암환자적림상자료.결과 단인소분석결과현시,환자년령、시부절경、종류대소、병리류형화맥관류전균여전초림파결전이(SLNM)유관(균P＜0.05)；년령、악성종류가족사、절경정황、국부절제술、시종기술、전초림파결양성、종류대소、병리류형、분화정도、자격소수체(ER)양성、잉격소수체양성、인표피생장인자수체2양성수목、맥관류전화Ki-67≥15％등균여비전초림파결전이무관(균P＞0.05).Logistic회귀분석결과현시,환자년령、종류대소화맥관류전균여SLNM유관(균P＜0.05).결론 환자년령、종류대소화맥관류전시영향SLNM적독립인소,기중년령시보호인소.이병리류형、병리분급화ER상태시부여SLNM유관존재쟁의.
Objective To explore the relevant factors influencing sentinel and non-sentinel lymph node (SLNM,NSLNM) metastases in breast cancer.Methods The clinicopathological data of 283 women with breast cancer who underwent sentinel lymph node biopsy from July 2010 to August 2011 in the Cancer Institute and Hospital at Chinese Academy of Medical Sciences were reviewed retrospectively,and the relevant factors affecting sentinel and non-sentinel lymph node metastases were analyzed.Results Univariate analysis showed that age,menopause status,tumor size,pathological type and intravascular tumor thrombus were asssociated with SLNM metastasis (all P ＜ 0.05).Multivariate analysis showed that age,tumor size and intravascular tumor thrombus were asssociated with SLNM (all P ＜ 0.05).No risk factors were found in either univariate or multivariate analysis of NSLNM.Conclusions Age,tumor size and intravascular tumor thrombus are independent influencing factors associated with SLNM,and age is a protective factor.Whether ER,pathological type and pathological grade are associated with SLNM or not is still controversial.