中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2013年
10期
796-800
,共5页
胡晓凤%姜勇%曲宸绪%王建炳%陈万青%李辉%乔友林
鬍曉鳳%薑勇%麯宸緒%王建炳%陳萬青%李輝%喬友林
호효봉%강용%곡신서%왕건병%진만청%리휘%교우림
乳腺肿瘤%危险因素%人群归因分值%发病率%死亡
乳腺腫瘤%危險因素%人群歸因分值%髮病率%死亡
유선종류%위험인소%인군귀인분치%발병솔%사망
Breast neoplasms%Risk factors%Population attributable fraction%Incidence%Death
目的 评估已知乳腺癌危险因素对我国女性人群的人群归因危险,为中国女性乳腺癌的预防与控制提供依据.方法 利用文献中人群暴露率和相对危险度的数据,计算已知危险因素的人群归因分值(PAF),并利用全国第三次死因调查的数据估计乳腺癌的归因死亡和发病人数.人群暴露率的数据主要来源于大样本、大范围的代表全国人群的调查数据,相对危险度的数据来自Meta分析研究和中国或其他国家的大样本的单个研究资料.结果 居前5位的乳腺癌发病的危险因素依次为良性乳腺疾病(RR =2.62)、乳腺癌家族史(RR =2.39)、吸烟(RR=l.86)、超重(RR=1.60)和月经初潮年龄(RR=l.54).生殖因素、生活方式、良性乳腺疾病、外源性激素治疗及乳腺癌家族史的PAF分别为27.84％、23.55％、15.09％、3.60％和2.49％,五大危险因素总PAF为55.95％.2005年,我国女性乳腺癌归因于生殖因素、生活方式、良性乳腺疾病、外源性激素治疗及乳腺癌家族史的发病和死亡人数分别为79 862和22 456例.结论 预防控制各种不良生活方式将可能显著降低中国乳腺癌发病与死亡.
目的 評估已知乳腺癌危險因素對我國女性人群的人群歸因危險,為中國女性乳腺癌的預防與控製提供依據.方法 利用文獻中人群暴露率和相對危險度的數據,計算已知危險因素的人群歸因分值(PAF),併利用全國第三次死因調查的數據估計乳腺癌的歸因死亡和髮病人數.人群暴露率的數據主要來源于大樣本、大範圍的代錶全國人群的調查數據,相對危險度的數據來自Meta分析研究和中國或其他國傢的大樣本的單箇研究資料.結果 居前5位的乳腺癌髮病的危險因素依次為良性乳腺疾病(RR =2.62)、乳腺癌傢族史(RR =2.39)、吸煙(RR=l.86)、超重(RR=1.60)和月經初潮年齡(RR=l.54).生殖因素、生活方式、良性乳腺疾病、外源性激素治療及乳腺癌傢族史的PAF分彆為27.84％、23.55％、15.09％、3.60％和2.49％,五大危險因素總PAF為55.95％.2005年,我國女性乳腺癌歸因于生殖因素、生活方式、良性乳腺疾病、外源性激素治療及乳腺癌傢族史的髮病和死亡人數分彆為79 862和22 456例.結論 預防控製各種不良生活方式將可能顯著降低中國乳腺癌髮病與死亡.
목적 평고이지유선암위험인소대아국녀성인군적인군귀인위험,위중국녀성유선암적예방여공제제공의거.방법 이용문헌중인군폭로솔화상대위험도적수거,계산이지위험인소적인군귀인분치(PAF),병이용전국제삼차사인조사적수거고계유선암적귀인사망화발병인수.인군폭로솔적수거주요래원우대양본、대범위적대표전국인군적조사수거,상대위험도적수거래자Meta분석연구화중국혹기타국가적대양본적단개연구자료.결과 거전5위적유선암발병적위험인소의차위량성유선질병(RR =2.62)、유선암가족사(RR =2.39)、흡연(RR=l.86)、초중(RR=1.60)화월경초조년령(RR=l.54).생식인소、생활방식、량성유선질병、외원성격소치료급유선암가족사적PAF분별위27.84％、23.55％、15.09％、3.60％화2.49％,오대위험인소총PAF위55.95％.2005년,아국녀성유선암귀인우생식인소、생활방식、량성유선질병、외원성격소치료급유선암가족사적발병화사망인수분별위79 862화22 456례.결론 예방공제각충불량생활방식장가능현저강저중국유선암발병여사망.
Objective To estimate the contribution of known identified risk factors to breast cancer incidence and mortality in China,and provide evidence to support the prevention and control of breast cancer for Chinese females.Methods We calculated the proportion of breast cancer attributable to specific risk factors.Data on exposure prevalence were obtained from Meta-analyses and large-scale national surveys of representative samples of the Chinese population.Data on relative risks were obtained from Meta-analyses and large-scale prospective studies.Cancer mortality and incidence were taken from the Third National Death Survey and from cancer registries in China.Results The first 5 risk factors of breast cancer in China were benign breast disease (RR =2.62),family history of breast cancer (RR =2.39),smoking (RR =1.86),overweight (RR =1.60) and age at menarche (RR =1.54).The proportion of breast cancer deaths attributable to reproductive factors,lifestyle factors,benign breast disease,the use of external hormone and family history of breast cancer was 27.84％,23.55％,15.09％,3.60％ and 2.49％,respectively.The total poPulation attributable fraction (PAF) was 55.95％ for risk factors in our study.Overall,we estimated that 79 862 breast cancer cases and 22 456 deaths were attributed to the five risk factors in China in 2005.Conclusions The prevention and control of unhealthy lifestyle factors may significantly reduce the number and death of breast cancer in China.
