CAJ | 학술논문

目的探讨早期乳腺癌前哨淋巴结阳性的预测因素.方法回顾性分析2010年7月至2013年8月河南省肿瘤医院收治的1 038例接受前哨淋巴结活检术患者的临床病理资料.各项临床病理特征与前哨淋巴结转移的相关性分析采用Logistic回归模型.结果全组患者均为女性,年龄22 ～ 84岁,平均48.6岁;前哨淋巴结的平均检出数为3.8枚.1 038例早期乳腺癌患者的前哨淋巴结转移率为22.9％ (238/1 038).单因素分析显示,肿瘤大小、肿瘤位置、病理类型、激素受体状态和Ki-67标记指数与前哨淋巴结的转移有关(均P＜0.05).多因素分析显示,肿瘤位置、肿瘤大小、病理类型和激素受体状态是前哨淋巴结转移的独立预测因素(OR分别为2.940、4.278、4.097和2.926,均P＜0.05).结论激素受体阴性、浸润性非特殊类型癌、肿瘤直径＞2 cm和肿瘤位于外上象限是早期乳腺癌前哨淋巴结转移的独立不良因素.
목적 탐토조기유선암전초림파결양성적예측인소.방법 회고성분석2010년7월지2013년8월하남성종류의원수치적1 038례접수전초림파결활검술환자적림상병리자료.각항림상병리특정여전초림파결전이적상관성분석채용Logistic회귀모형.결과 전조환자균위녀성,년령22 ～ 84세,평균48.6세;전초림파결적평균검출수위3.8매.1 038례조기유선암환자적전초림파결전이솔위22.9％ (238/1 038).단인소분석현시,종류대소、종류위치、병리류형、격소수체상태화Ki-67표기지수여전초림파결적전이유관(균P＜0.05).다인소분석현시,종류위치、종류대소、병리류형화격소수체상태시전초림파결전이적독립예측인소(OR분별위2.940、4.278、4.097화2.926,균P＜0.05).결론 격소수체음성、침윤성비특수류형암、종류직경＞2 cm화종류위우외상상한시조기유선암전초림파결전이적독립불량인소.
Objective To investigate the predictive factors affecting sentinel lymph node status in early breast cancer patients.Methods Clinicopathological data of 1 038 patients with early breast cancer,who underwent sentinel lymph node biopsy in Henan Tumor Hospital between July 2010 and August 2013,were reviewed.Logistic regression analysis was performed to identify the relevance of clinicopathological features with sentinel lymph node metastases.Results This group was consisted of 1 038 female patients with an average of 48.6 years.Positive sentinel lymph nodes were found in 22.9％ (238/1 038) of the patients.The average number of sentinel lymph nodes removed by surgery was 3.8.Tumor size,tumor location,histopathology,ER/PR status and Ki-67 level were significantly correlated with SLN metastasis (P ＜ 0.05 for all).All the above factors but Ki-67 level were significant independent predictors for SLN metastasis(P ＜ 0.01 for all).Conclusion Negative hormone receptor status,invasive cancer of nonspecific histopathological type,tumor size ＞ 2 cm,and tumor location in the outer upper quadrat are indcpendent predictive factors of sentinel lymph node metastasis in patients with early breast cancer.