中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2014年
4期
273-275
,共3页
王宝娜%王翔%王靖%宣立学%王仲照%王昕%高纪东%张海增
王寶娜%王翔%王靖%宣立學%王仲照%王昕%高紀東%張海增
왕보나%왕상%왕정%선립학%왕중조%왕흔%고기동%장해증
乳腺肿瘤%预后%基因表达%Ki67
乳腺腫瘤%預後%基因錶達%Ki67
유선종류%예후%기인표체%Ki67
Breast neoplasms%Prognosis%Gene expression%Ki67
目的 探讨Ki67指数与乳腺癌其他临床病理指标的关系.方法 回顾性分析中国医学科学院肿瘤医院2010年1月至2010年12月收治的918例女性乳腺浸润性导管癌患者的临床病理资料,分析Ki67指数与乳腺癌其他临床病理指标的关系.结果 918例女性乳腺癌患者的Ki67指数为0.9％～95％,平均为27.8％.以Ki67指数14％为界将患者分为2组,其中Ki67指数≤14％者263例(28.6％),Ki67指数＞14％者655例(71.4％).患者年龄、肿瘤T分期、腋窝淋巴结转移状态、组织学分级、雌激素受体(ER)状态、孕激素受体(PR)状态和人表皮生长因子受体2(HER-2)状态均与Ki67指数有关(均P＜0.05).Luminal B型、HER-2过表达型和三阴性乳腺癌的Ki67指数分别为30.44％、36.77％和47.40％,均高于Luminal A型(21.36％,P＜0.01).三阴性乳腺癌Ki67指数(47.40％)高于非三阴性乳腺癌(24.79％,P＜0.001).结论 Ki67指数与患者年龄、肿瘤T分期、腋窝淋巴结转移状态、组织学分级、ER状态、PR状态和HER-2状态均有关,有望成为判断乳腺癌预后的重要指标.
目的 探討Ki67指數與乳腺癌其他臨床病理指標的關繫.方法 迴顧性分析中國醫學科學院腫瘤醫院2010年1月至2010年12月收治的918例女性乳腺浸潤性導管癌患者的臨床病理資料,分析Ki67指數與乳腺癌其他臨床病理指標的關繫.結果 918例女性乳腺癌患者的Ki67指數為0.9％～95％,平均為27.8％.以Ki67指數14％為界將患者分為2組,其中Ki67指數≤14％者263例(28.6％),Ki67指數＞14％者655例(71.4％).患者年齡、腫瘤T分期、腋窩淋巴結轉移狀態、組織學分級、雌激素受體(ER)狀態、孕激素受體(PR)狀態和人錶皮生長因子受體2(HER-2)狀態均與Ki67指數有關(均P＜0.05).Luminal B型、HER-2過錶達型和三陰性乳腺癌的Ki67指數分彆為30.44％、36.77％和47.40％,均高于Luminal A型(21.36％,P＜0.01).三陰性乳腺癌Ki67指數(47.40％)高于非三陰性乳腺癌(24.79％,P＜0.001).結論 Ki67指數與患者年齡、腫瘤T分期、腋窩淋巴結轉移狀態、組織學分級、ER狀態、PR狀態和HER-2狀態均有關,有望成為判斷乳腺癌預後的重要指標.
목적 탐토Ki67지수여유선암기타림상병리지표적관계.방법 회고성분석중국의학과학원종류의원2010년1월지2010년12월수치적918례녀성유선침윤성도관암환자적림상병리자료,분석Ki67지수여유선암기타림상병리지표적관계.결과 918례녀성유선암환자적Ki67지수위0.9％～95％,평균위27.8％.이Ki67지수14％위계장환자분위2조,기중Ki67지수≤14％자263례(28.6％),Ki67지수＞14％자655례(71.4％).환자년령、종류T분기、액와림파결전이상태、조직학분급、자격소수체(ER)상태、잉격소수체(PR)상태화인표피생장인자수체2(HER-2)상태균여Ki67지수유관(균P＜0.05).Luminal B형、HER-2과표체형화삼음성유선암적Ki67지수분별위30.44％、36.77％화47.40％,균고우Luminal A형(21.36％,P＜0.01).삼음성유선암Ki67지수(47.40％)고우비삼음성유선암(24.79％,P＜0.001).결론 Ki67지수여환자년령、종류T분기、액와림파결전이상태、조직학분급、ER상태、PR상태화HER-2상태균유관,유망성위판단유선암예후적중요지표.
Objective To analyze the relationship between the expression level of Ki67 and clinicopathological features in breast cancer.Methods Data of 918 female patients with invasive ductal breast carcinoma treated in the Cancer Hospital,Chinese Academy of Medical Sciences from Jan.to Dec.2010 were analyzed retrospectively.The correlation of Ki67 expression and other clinicopathological features in the breast cancer was analyzed.Results Among the 918 cases,the Ki67 index was 0.9％ to 95％ (mean value 27.8％).Taking the Ki67 index 14％ as the boundary to divide the patients into two subgroups,263 cases (28.6％) were ≤ 14％,and 655 cases (71.4％) were ＞ 14％.There were significant differences between the Ki67 expression and age,tumor size,axillary lymph nodes status,histological grade and the expressions of C-erbB-2,estrogen receptor (ER) and progesterone receptor (PR) (P ＜ 0.05 for all).All the Ki67 indexes of Ki67 expression in luminal B (30.44％),HER-2 overexpression (36.77％) and triple negative (47.40％) subtypes were significantly higher than that in the luminal A subtype (21.36％) (P ＜ 0.01).The expression level of Ki67 in triple-negative subtype (47.40％) was significantly higher than that in the non-triple-negative subtype (24.79％) (P ＜ 0.001).Conclusions Ki67 index is significantly correlated with the age,tumor TNM stage,axillary lymph node status,histological grading,ER status,PR status and HER-2 status.A high expression level of Ki67 is a poor prognostic factor for breast cancer.The expression level of Ki67 should be detected routinely and it may become a useful prognostic marker in the treatment of breast cancer.
