中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2014年
6期
476-480
,共5页
崔剑峰%杜旌畅%费满冬%何微%张韶凯%游嘉%司玉芝%樊小平%陈汶
崔劍峰%杜旌暢%費滿鼕%何微%張韶凱%遊嘉%司玉芝%樊小平%陳汶
최검봉%두정창%비만동%하미%장소개%유가%사옥지%번소평%진문
宫颈肿瘤%戊型肝炎病毒抗体%人乳头状瘤病毒抗体%酶链免疫吸附试验%危险因素
宮頸腫瘤%戊型肝炎病毒抗體%人乳頭狀瘤病毒抗體%酶鏈免疫吸附試驗%危險因素
궁경종류%무형간염병독항체%인유두상류병독항체%매련면역흡부시험%위험인소
Uterine cervical neoplasms%HEV antibody%HPV L1 antibody%Enzyme-linked immunosorbent assay%Risk factors
目的 研究女性人群戊型肝炎病毒抗体(HEV-IgG)和人乳头状瘤病毒抗体(HPV L1-IgG)的分布情况以及危险因素,探讨HEV疫苗免疫人群作为HPV疫苗人群免疫效果评价对照组的可行性.方法 对河南省新密地区952例女性人群进行筛查研究,通过问卷调查获得其人口学特征与危险因素.取每名受试者9 ml外周血,采用酶联免疫吸附方法检测同一研究对象HEV-IgG和HPV L1-IgG的水平.采用Logistic回归分析的方法描述影响HEV-IgG与HPV L1-IgG表达的危险因素.结果 研究人群的平均年龄为47.2岁,农民所占的比例为85.8%,低收入人群占44.5%.952例研究人群中,HPV L1-IgG的阳性率为26.8% (255/952),HEV-IgG的阳性率为31.0% (295/952),HEV-IgG与HPV L1-IgG的表达无关(P=0.749).HEV-IgG与HPV L1-IgG的表达水平基本随年龄增长而升高,不同年龄组的表达差异有统计学意义(均P <0.001).多因素分析显示,年龄(OR=1.050,95% CI为1.031 ~1.069)、是否为低收入人群(OR=1.341,95% CI为1.004 ~1.790)、是否为农民(OR=0.604,95% CI为0.402~0.906)为HEV-IgG阳性影响因素;年龄(OR=1.022,95% CI为1.001 ~1.043)、初次性生活年龄(OR=0.923,95% CI为0.861 ~0.990)、是否接受过教育(OR=0.630,95%CI为0.423 ~0.939)为HPV L1-IgG阳性影响因素.结论 新密地区女性人群HEV-IgG与HPV L1-IgG的阳性率基本随年龄增长而升高;年龄是HEV-IgG与HPV L1-IgG的共同危险因素;HEV-IgG与HPV L1-IgG的检测未见交叉反应.
目的 研究女性人群戊型肝炎病毒抗體(HEV-IgG)和人乳頭狀瘤病毒抗體(HPV L1-IgG)的分佈情況以及危險因素,探討HEV疫苗免疫人群作為HPV疫苗人群免疫效果評價對照組的可行性.方法 對河南省新密地區952例女性人群進行篩查研究,通過問捲調查穫得其人口學特徵與危險因素.取每名受試者9 ml外週血,採用酶聯免疫吸附方法檢測同一研究對象HEV-IgG和HPV L1-IgG的水平.採用Logistic迴歸分析的方法描述影響HEV-IgG與HPV L1-IgG錶達的危險因素.結果 研究人群的平均年齡為47.2歲,農民所佔的比例為85.8%,低收入人群佔44.5%.952例研究人群中,HPV L1-IgG的暘性率為26.8% (255/952),HEV-IgG的暘性率為31.0% (295/952),HEV-IgG與HPV L1-IgG的錶達無關(P=0.749).HEV-IgG與HPV L1-IgG的錶達水平基本隨年齡增長而升高,不同年齡組的錶達差異有統計學意義(均P <0.001).多因素分析顯示,年齡(OR=1.050,95% CI為1.031 ~1.069)、是否為低收入人群(OR=1.341,95% CI為1.004 ~1.790)、是否為農民(OR=0.604,95% CI為0.402~0.906)為HEV-IgG暘性影響因素;年齡(OR=1.022,95% CI為1.001 ~1.043)、初次性生活年齡(OR=0.923,95% CI為0.861 ~0.990)、是否接受過教育(OR=0.630,95%CI為0.423 ~0.939)為HPV L1-IgG暘性影響因素.結論 新密地區女性人群HEV-IgG與HPV L1-IgG的暘性率基本隨年齡增長而升高;年齡是HEV-IgG與HPV L1-IgG的共同危險因素;HEV-IgG與HPV L1-IgG的檢測未見交扠反應.
목적 연구녀성인군무형간염병독항체(HEV-IgG)화인유두상류병독항체(HPV L1-IgG)적분포정황이급위험인소,탐토HEV역묘면역인군작위HPV역묘인군면역효과평개대조조적가행성.방법 대하남성신밀지구952례녀성인군진행사사연구,통과문권조사획득기인구학특정여위험인소.취매명수시자9 ml외주혈,채용매련면역흡부방법검측동일연구대상HEV-IgG화HPV L1-IgG적수평.채용Logistic회귀분석적방법묘술영향HEV-IgG여HPV L1-IgG표체적위험인소.결과 연구인군적평균년령위47.2세,농민소점적비례위85.8%,저수입인군점44.5%.952례연구인군중,HPV L1-IgG적양성솔위26.8% (255/952),HEV-IgG적양성솔위31.0% (295/952),HEV-IgG여HPV L1-IgG적표체무관(P=0.749).HEV-IgG여HPV L1-IgG적표체수평기본수년령증장이승고,불동년령조적표체차이유통계학의의(균P <0.001).다인소분석현시,년령(OR=1.050,95% CI위1.031 ~1.069)、시부위저수입인군(OR=1.341,95% CI위1.004 ~1.790)、시부위농민(OR=0.604,95% CI위0.402~0.906)위HEV-IgG양성영향인소;년령(OR=1.022,95% CI위1.001 ~1.043)、초차성생활년령(OR=0.923,95% CI위0.861 ~0.990)、시부접수과교육(OR=0.630,95%CI위0.423 ~0.939)위HPV L1-IgG양성영향인소.결론 신밀지구녀성인군HEV-IgG여HPV L1-IgG적양성솔기본수년령증장이승고;년령시HEV-IgG여HPV L1-IgG적공동위험인소;HEV-IgG여HPV L1-IgG적검측미견교차반응.
Objective Investigating the distribution of anti-hepatitis E virus (HEV-IgG),antihuman papillomavirus (HPV L1-IgG) and risk factors among female residents in Xinmi County,to explore the influencing factors of HPV vaccine study using HEV vaccinated population as a control.Methods A screening study of cervical cancer in Xinmi County,Henan Province,was performed.The information of demographic characteristics and risk factors was collected using standard questionnaire.Nine ml blood was drawn from each woman for enzyme-linked immunosorbent assay to detect HEV-IgG and HPV L1-IgG antibody.Percentile,histogram and binary logistic regression model were used to describe the distribution of risk factors and their correlation to HPV and HEV infection.Results The average age of the Xinmi female residents was 47.2 years,their positive rate of HPV L1 antibody was 26.8%,and that of HEV-IgG antibody was 31.0%,both of which were raised with age (P <0.001).Single factor analysis showed that non-education,low-income and growing age were associated with HEV-IgG antibody positivity,and non-education,lowering ages of first sexual life and growing age were associated with HPV L1-IgG antibodypositivity.Multivariable analysis showed that growing age,low-income and work as peasantry were independent risk factors for HEV-IgG antibody positivity,and lowering ages of first sexual life,non-education and growing age were independent risk factors for HPV L1-IgG antibody positivity.Conclusions Both the HEV-IgG and HPV L1-IgG antibodies positive rates increase with age.Age is the common risk factor of HEV-IgG and HPV L1-IgG antibodies in female residents in Ximi County.The risk factors of HEV-IgG and HPV L1-IgG antibodies have no statistical association,neither cross reaction was found in the HEV-IgG and HPV L1-IgG detection.