中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2014年
8期
606-611
,共6页
于学娟%柳善刚%陈兆秋%张品良%张建波%徐亮%刘增军%任瑞美
于學娟%柳善剛%陳兆鞦%張品良%張建波%徐亮%劉增軍%任瑞美
우학연%류선강%진조추%장품량%장건파%서량%류증군%임서미
[主题词]乳腺肿瘤%磁共振成像,弥散%表观扩散系数%组织学分级%受体,雌激素%受体,孕激素%Ki-67
[主題詞]乳腺腫瘤%磁共振成像,瀰散%錶觀擴散繫數%組織學分級%受體,雌激素%受體,孕激素%Ki-67
[주제사]유선종류%자공진성상,미산%표관확산계수%조직학분급%수체,자격소%수체,잉격소%Ki-67
Breast neoplasms%Diffusion magnetic resonance imaging%Apparent diffusion coefficient%Histological grade%Receptors,estrogen%Receptors,progesterone%Ki-67
目的 分析3.0T磁共振成像(3.0T-MRI)表观扩散系数(ADC)与乳腺浸润性导管癌组织学分级和分子生物学特征的相关性.方法 收集2010年2月至2013年2月间经手术病理证实的125例乳腺浸润性导管癌患者,患者术前均行常规3.0T-MRI和扩散加权成像(DWI)检查,扩散敏感系数(b值)为0和800 s/mm2,在ADC图上,于病灶最大层面和(或)其上下两层面选取感兴趣区(ROI)测量ADC值.分析其与病理分级和生物因子表达间的相关性.结果 Ⅰ、Ⅱ、Ⅲ级乳腺浸润性导管癌的ADC值分别为(1.152±0.072)×10-3、(1.102±0.101)×10-3和(1.035±0.107)×10-3mm2/s,差异有统计学意义(P =0.003).Ⅲ级乳腺浸润性导管癌的ADC值与Ⅰ、Ⅱ级乳腺浸润性导管癌的ADC值间差异均有统计学意义(P =0.034,P=0.006),Ⅰ级乳腺浸润性导管癌的ADC值与Ⅱ级乳腺浸润性导管癌的ADC值间差异无统计学意义(P=0.741).乳腺浸润性导管癌病理分级与ADC值呈负相关(r=-0.342,P＜0.001).125例乳腺浸润性导管癌患者中,雌激素受体(ER)阳性组和阴性组的ADC值分别为(1.060±0.089)×10-3和(1.130±0.115)×10-3 mm2/s(P＜0.001),孕激素受体(PR)阳性组和阴性组的ADC值分别为(1.055 ±0.096)×10-3 mm2/s和(1.121±0.106)×10-3mm2/s(P＜0.001),Ki-67阳性组和阴性组的ADC值分别为(1.063±0.101)×10-3 mm2/s和(1.153±0.090) ×10-3 mm2/s (P ＜0.001).乳腺浸润性导管癌的ADC值与ER、PR和Ki-67的表达呈负相关(r分别为-0.311、-0.317、-0.414,均P＜0.001).结论 ADC值与乳腺浸润性导管癌组织学分级和ER、PR、Ki-67的表达存在一定相关性.
目的 分析3.0T磁共振成像(3.0T-MRI)錶觀擴散繫數(ADC)與乳腺浸潤性導管癌組織學分級和分子生物學特徵的相關性.方法 收集2010年2月至2013年2月間經手術病理證實的125例乳腺浸潤性導管癌患者,患者術前均行常規3.0T-MRI和擴散加權成像(DWI)檢查,擴散敏感繫數(b值)為0和800 s/mm2,在ADC圖上,于病竈最大層麵和(或)其上下兩層麵選取感興趣區(ROI)測量ADC值.分析其與病理分級和生物因子錶達間的相關性.結果 Ⅰ、Ⅱ、Ⅲ級乳腺浸潤性導管癌的ADC值分彆為(1.152±0.072)×10-3、(1.102±0.101)×10-3和(1.035±0.107)×10-3mm2/s,差異有統計學意義(P =0.003).Ⅲ級乳腺浸潤性導管癌的ADC值與Ⅰ、Ⅱ級乳腺浸潤性導管癌的ADC值間差異均有統計學意義(P =0.034,P=0.006),Ⅰ級乳腺浸潤性導管癌的ADC值與Ⅱ級乳腺浸潤性導管癌的ADC值間差異無統計學意義(P=0.741).乳腺浸潤性導管癌病理分級與ADC值呈負相關(r=-0.342,P＜0.001).125例乳腺浸潤性導管癌患者中,雌激素受體(ER)暘性組和陰性組的ADC值分彆為(1.060±0.089)×10-3和(1.130±0.115)×10-3 mm2/s(P＜0.001),孕激素受體(PR)暘性組和陰性組的ADC值分彆為(1.055 ±0.096)×10-3 mm2/s和(1.121±0.106)×10-3mm2/s(P＜0.001),Ki-67暘性組和陰性組的ADC值分彆為(1.063±0.101)×10-3 mm2/s和(1.153±0.090) ×10-3 mm2/s (P ＜0.001).乳腺浸潤性導管癌的ADC值與ER、PR和Ki-67的錶達呈負相關(r分彆為-0.311、-0.317、-0.414,均P＜0.001).結論 ADC值與乳腺浸潤性導管癌組織學分級和ER、PR、Ki-67的錶達存在一定相關性.
목적 분석3.0T자공진성상(3.0T-MRI)표관확산계수(ADC)여유선침윤성도관암조직학분급화분자생물학특정적상관성.방법 수집2010년2월지2013년2월간경수술병리증실적125례유선침윤성도관암환자,환자술전균행상규3.0T-MRI화확산가권성상(DWI)검사,확산민감계수(b치)위0화800 s/mm2,재ADC도상,우병조최대층면화(혹)기상하량층면선취감흥취구(ROI)측량ADC치.분석기여병리분급화생물인자표체간적상관성.결과 Ⅰ、Ⅱ、Ⅲ급유선침윤성도관암적ADC치분별위(1.152±0.072)×10-3、(1.102±0.101)×10-3화(1.035±0.107)×10-3mm2/s,차이유통계학의의(P =0.003).Ⅲ급유선침윤성도관암적ADC치여Ⅰ、Ⅱ급유선침윤성도관암적ADC치간차이균유통계학의의(P =0.034,P=0.006),Ⅰ급유선침윤성도관암적ADC치여Ⅱ급유선침윤성도관암적ADC치간차이무통계학의의(P=0.741).유선침윤성도관암병리분급여ADC치정부상관(r=-0.342,P＜0.001).125례유선침윤성도관암환자중,자격소수체(ER)양성조화음성조적ADC치분별위(1.060±0.089)×10-3화(1.130±0.115)×10-3 mm2/s(P＜0.001),잉격소수체(PR)양성조화음성조적ADC치분별위(1.055 ±0.096)×10-3 mm2/s화(1.121±0.106)×10-3mm2/s(P＜0.001),Ki-67양성조화음성조적ADC치분별위(1.063±0.101)×10-3 mm2/s화(1.153±0.090) ×10-3 mm2/s (P ＜0.001).유선침윤성도관암적ADC치여ER、PR화Ki-67적표체정부상관(r분별위-0.311、-0.317、-0.414,균P＜0.001).결론 ADC치여유선침윤성도관암조직학분급화ER、PR、Ki-67적표체존재일정상관성.
Objective To study the correlation between the MRI apparent diffusion coefficient (ADC) value and histological grade and molecular biology of breast invasive ductal carcinoma (IDC).Methods This retrospective study included 125 patients with IDC verified by pathology from February 2010 to February 2013.Conventional MRI and diffusion-weighted imaging (DWI) examination were performed using a 3.0T scanner with diffusion factor of 0 and 800 s/mm2.The region of interest (ROI) was drawn on the largest lesion and/or its two adjacent slices.The ADC value of the whole tumor was calculated as the mean ADC value.The correlation between mean ADCs and histological grade and biological factors was analyzed.Results The mean ADC of pathological grade Ⅰ,Ⅱ and Ⅲ IDC was (1.152 ± 0.072) × 10-3 mm2/s,(1.102 ± 0.101) × 10-3 mm2/s,and (1.035 ± 0.107) × 10-3 mm2/s,respectively.There was a statistically significant difference among them (P =0.003).Statistically a significant difference was observed between grade Ⅲ and Ⅰ (P =0.034),grade Ⅲ and Ⅱ (P =0.006),but not between grade Ⅰ and Ⅱ (P =0.741).A significant correlation was observed between ADC value and pathological grade (r =-0.342,P ＜ 0.001).The median ADC values were significantly higher in the ER-negative than in the ER-positive cases [(1.130 ±0.115) × 10-3 mm2/s vs.(1.060 ± 0.089) × 10-3 mm2/s,p ＜ 0.001)],in PR-negative than in PR-positive cases [(1.121 ± 0.106) × 10-3 mm2/s vs.(1.055 ± 0.096) × 10-3 mm2/s,P ＜0.001)],and in Ki-67-negative than in Ki-67-positive cases [(1.153 ±0.090) × 10-3 mm2/s vs.(1.063 ± 0.101) × 10-3 mm2/s,p ＜ 0.001].A statistically significant correlation was observed between ADC value and expressions of ER,PR,and Ki-67 (r ＝-0.311,r =-0.317,r =-0.414,P ＜0.001).Conclusion ADC value of breast invasive ductal carcinoma is correlated with histological grade,and expression of ER,PR and Ki-67.
