中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2014年
8期
626-628
,共3页
王涛%刘跃华%郑和义%左亚刚%方凯
王濤%劉躍華%鄭和義%左亞剛%方凱
왕도%류약화%정화의%좌아강%방개
淋巴瘤,T细胞,皮肤%真菌病,蕈样%PUVA疗法%紫外线疗法%治疗效果
淋巴瘤,T細胞,皮膚%真菌病,蕈樣%PUVA療法%紫外線療法%治療效果
림파류,T세포,피부%진균병,심양%PUVA요법%자외선요법%치료효과
Lymphoma,T-cell,cutaneous%Mycosis fungoides%PUVA therapy%Ultraviolet therapy%Treatment outcome
目的 分析甲氧沙林加紫外线A(PUVA)联合窄谱中波紫外线B(NB-UVB)治疗早期蕈样肉芽肿(MF)的疗效.方法 24例经病理检查证实的早期MF患者,分别行PUVA治疗(9例)、NB-UVB治疗(6例)以及PUVA治疗好转后行NB-UVB的联合治疗(9例),分析患者的性别、发病年龄、TNM分期、治疗方法、治疗时间、治疗次数、维持治疗时间、预后及复发情况.结果 24例MF患者的平均治疗次数为104.5次(95％ CI为75.71～133.29次),平均治疗时间为12.88个月(95％ CI为9.90 ～ 15.85个月),平均维持治疗时间为11.08个月(95％ CI为2.13 ～20.04).PUVA组患者的治疗有效率为88.9％,复发率为11.1％.NB-UVB组患者的治疗有效率为100.0％,复发率为33.3％.PUVA和NB-UVB联合组患者的治疗有效率为77.8％,复发率为55.6％.PUVA组、NB-UVB组、PUVA和NB-UVB联合组患者的治疗次数、治疗时间、维持治疗时间、治疗有效率和复发率差异均无统计学意义(均P ＞0.05).结论 PUVA和NB-UVB是治疗早期MF有效的皮肤靶向治疗方法.PUVA和NB-UVB联合治疗的方法可减少PUVA的总摄入量,减少了潜在的致癌风险.
目的 分析甲氧沙林加紫外線A(PUVA)聯閤窄譜中波紫外線B(NB-UVB)治療早期蕈樣肉芽腫(MF)的療效.方法 24例經病理檢查證實的早期MF患者,分彆行PUVA治療(9例)、NB-UVB治療(6例)以及PUVA治療好轉後行NB-UVB的聯閤治療(9例),分析患者的性彆、髮病年齡、TNM分期、治療方法、治療時間、治療次數、維持治療時間、預後及複髮情況.結果 24例MF患者的平均治療次數為104.5次(95％ CI為75.71～133.29次),平均治療時間為12.88箇月(95％ CI為9.90 ～ 15.85箇月),平均維持治療時間為11.08箇月(95％ CI為2.13 ～20.04).PUVA組患者的治療有效率為88.9％,複髮率為11.1％.NB-UVB組患者的治療有效率為100.0％,複髮率為33.3％.PUVA和NB-UVB聯閤組患者的治療有效率為77.8％,複髮率為55.6％.PUVA組、NB-UVB組、PUVA和NB-UVB聯閤組患者的治療次數、治療時間、維持治療時間、治療有效率和複髮率差異均無統計學意義(均P ＞0.05).結論 PUVA和NB-UVB是治療早期MF有效的皮膚靶嚮治療方法.PUVA和NB-UVB聯閤治療的方法可減少PUVA的總攝入量,減少瞭潛在的緻癌風險.
목적 분석갑양사림가자외선A(PUVA)연합착보중파자외선B(NB-UVB)치료조기심양육아종(MF)적료효.방법 24례경병리검사증실적조기MF환자,분별행PUVA치료(9례)、NB-UVB치료(6례)이급PUVA치료호전후행NB-UVB적연합치료(9례),분석환자적성별、발병년령、TNM분기、치료방법、치료시간、치료차수、유지치료시간、예후급복발정황.결과 24례MF환자적평균치료차수위104.5차(95％ CI위75.71～133.29차),평균치료시간위12.88개월(95％ CI위9.90 ～ 15.85개월),평균유지치료시간위11.08개월(95％ CI위2.13 ～20.04).PUVA조환자적치료유효솔위88.9％,복발솔위11.1％.NB-UVB조환자적치료유효솔위100.0％,복발솔위33.3％.PUVA화NB-UVB연합조환자적치료유효솔위77.8％,복발솔위55.6％.PUVA조、NB-UVB조、PUVA화NB-UVB연합조환자적치료차수、치료시간、유지치료시간、치료유효솔화복발솔차이균무통계학의의(균P ＞0.05).결론 PUVA화NB-UVB시치료조기MF유효적피부파향치료방법.PUVA화NB-UVB연합치료적방법가감소PUVA적총섭입량,감소료잠재적치암풍험.
Objective Only a few clinical reports in the treatment of early mycosis fungoides (MF) (Ⅰ A,Ⅰ B,Ⅱ A stage) are available in the literature.The purpose of this study was to compare the efficacy and safety of narrow-band UVB and psoralen plus ultraviolet A (PUVA) photochemoterapy in 24 patients with early-stage MF,and explore a new approach for the treatment of early mycosis fungoides.Methods A total of 24 identified early mycosis fungoides patients received PUVA,NB-UVB and a combined therapy of PUVA followed by NB-UVB (n =9/6/9) irradiation.A retrospective study was carried out to analyze the sex,age of onset,TNM stage,treatment,and duration of treatment,and times of treatment,duration of maintenance treatment,effective and recurrence in these patients.The data were analyzed using SPSS 17.0 and a two-sided test at the α =0.05 level of significance was conducted.Results Of the 24 patients studied,the average treatment was 104.5 (95％ CI,75.71-133.29) times.The average duration of treatment was 12.88 (95％ CI,9.90-15.85) months.The average maintenance treatment time was 11.08 (95％ CI,2.13-20.04) months.The effective rate (CR + PR) of PUVA treatment was 88.9％,recurrence rate was 11.1％ (n =9).In the NB-UVB treatment group,the effective rate was 100.0％,and the recurrence rate was 33.3％ (n =6).In the PUVA followed by NB-UVB (combination therapy) treatment group,the effective rate was 77.8％ and the recurrence rate was 55.6％ (n =9).There were no significant differences among the three groups in terms of number of treatments,treatment duration,maintenance treatment duration,effective rate and recurrence rate (P ＞ 0.05).Conclusious PUVA and NB-UVB are effective and safe in the targeted therapy of early stage mycosis fungoides.The combined therapy of PUVA followed by NB-UVB can reduce the total PUVA dose and risk of developing skin cancer.
