肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2009年
9期
614-615
,共2页
喉肿瘤%RhoB%逆转录聚合酶链反应
喉腫瘤%RhoB%逆轉錄聚閤酶鏈反應
후종류%RhoB%역전록취합매련반응
Laryngeal neoplasms%RhoB%Reverse transcriptase polymerase chain reaction
目的 研究RhoB-mRNA在喉癌组织、癌旁组织的表达情况,探讨其与喉癌的发生、发展以及转移之间的关系.方法 采用RT-PCR方法检测RhoB-mRNA的表达及分布情况.结果 RhoB-mRNA在喉癌组织的表达(2.02±1.157)低于癌旁组织(2.52±1.255)的表达,两组间比较差异有统计学意义(P＜0.05),RhoB-mRNA的表达在喉癌的不同分型、分期之间差异均有统计学意义(P＜0.05),RhoB在喉癌组织中的表达与喉癌的分期呈负相关(r=0.557).结论 RhoB蛋白基因在喉癌的发生、浸润以及淋巴结转移中起抑制作用.
目的 研究RhoB-mRNA在喉癌組織、癌徬組織的錶達情況,探討其與喉癌的髮生、髮展以及轉移之間的關繫.方法 採用RT-PCR方法檢測RhoB-mRNA的錶達及分佈情況.結果 RhoB-mRNA在喉癌組織的錶達(2.02±1.157)低于癌徬組織(2.52±1.255)的錶達,兩組間比較差異有統計學意義(P＜0.05),RhoB-mRNA的錶達在喉癌的不同分型、分期之間差異均有統計學意義(P＜0.05),RhoB在喉癌組織中的錶達與喉癌的分期呈負相關(r=0.557).結論 RhoB蛋白基因在喉癌的髮生、浸潤以及淋巴結轉移中起抑製作用.
목적 연구RhoB-mRNA재후암조직、암방조직적표체정황,탐토기여후암적발생、발전이급전이지간적관계.방법 채용RT-PCR방법검측RhoB-mRNA적표체급분포정황.결과 RhoB-mRNA재후암조직적표체(2.02±1.157)저우암방조직(2.52±1.255)적표체,량조간비교차이유통계학의의(P＜0.05),RhoB-mRNA적표체재후암적불동분형、분기지간차이균유통계학의의(P＜0.05),RhoB재후암조직중적표체여후암적분기정부상관(r=0.557).결론 RhoB단백기인재후암적발생、침윤이급림파결전이중기억제작용.
Objective To study the expression of RhoB-mRNA,and periphery regions in human laryngeal carcinoma.Methods The expression of RhoB-mRNA were examined by RT-PCR method.Results It was noted that the expression of RhoB-mRNA was positively correlated well with the clinical stages.The expression of RhoB-mRNA in carcinoma with node metastasis group was significantly higher than that without node metastasis.The difference between the two groups was statistically significant(P＜0.05).The expression of RhoB-mRNA in different types and stages of laryngeal carcinoma was significantly different(P＜0.05).The expression of RhoB in laryngeal carcinoma negtive correlation with the stages of laryngeal carcinoma(r=0.557).Conclusion The expression of RhoB plays an inhibitive role in the growth,invasion and local node metastasis of human laryngeal carcinoma.RhoB promote the formation,invasion and lymph node metastasis as oncogenes.It may be valuable as predictors for lymph node metastasis and prognosis.
