肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2012年
9期
610-612,619
,共4页
李井泉%王世亮%丁满志%陈殿良%祝牡丹%蒲永东
李井泉%王世亮%丁滿誌%陳殿良%祝牡丹%蒲永東
리정천%왕세량%정만지%진전량%축모단%포영동
肿瘤,实验性%吉西他滨%缓释%微球%急性毒性%半数致死量
腫瘤,實驗性%吉西他濱%緩釋%微毬%急性毒性%半數緻死量
종류,실험성%길서타빈%완석%미구%급성독성%반수치사량
Neoplasms,experimental%Gemcitabine%Slow-release%Microsphere%Acute toxicity%Lethal dose 50
目的 了解乳酸-乙醇酸共聚物(PLGA)-吉西他滨缓释微球和吉西他滨小鼠皮下给药的急性毒性.方法 采用上下增减剂量法(UDP)分别测定PLGA-吉西他滨缓释微球和吉西他滨小鼠皮下给药对动物的半数致死量(LD50).结果 PLGA-吉西他滨缓释微球皮下给药的小鼠LD50为256.30 mg/kg,吉西他滨小鼠皮下给药时为8.91 mg/kg,相差达28.8倍.结论 PLGA-吉西他滨缓释微球能够显著降低化疗药物对动物的急性毒性.
目的 瞭解乳痠-乙醇痠共聚物(PLGA)-吉西他濱緩釋微毬和吉西他濱小鼠皮下給藥的急性毒性.方法 採用上下增減劑量法(UDP)分彆測定PLGA-吉西他濱緩釋微毬和吉西他濱小鼠皮下給藥對動物的半數緻死量(LD50).結果 PLGA-吉西他濱緩釋微毬皮下給藥的小鼠LD50為256.30 mg/kg,吉西他濱小鼠皮下給藥時為8.91 mg/kg,相差達28.8倍.結論 PLGA-吉西他濱緩釋微毬能夠顯著降低化療藥物對動物的急性毒性.
목적 료해유산-을순산공취물(PLGA)-길서타빈완석미구화길서타빈소서피하급약적급성독성.방법 채용상하증감제량법(UDP)분별측정PLGA-길서타빈완석미구화길서타빈소서피하급약대동물적반수치사량(LD50).결과 PLGA-길서타빈완석미구피하급약적소서LD50위256.30 mg/kg,길서타빈소서피하급약시위8.91 mg/kg,상차체28.8배.결론 PLGA-길서타빈완석미구능구현저강저화료약물대동물적급성독성.
Objective To study the acute toxicity of slow-release (poly lactic-co-glycolic acid) PLGA-gemcitabine microsphere and gemcitabine on mice.Methods Up and down procedure (UDP) was used to determine the median lethal dose (LD50) of PLGA-gemcitabine microsphere and gemcitabine on mice respectively.Results The LD50 of PLGA-gemcitabine microsphere on mice was 256.30 mg/kg,gemcitabine was 8.91 mg/kg.The difference was 28.8 times.Conclusion PLGA-gemcitabine microsphere can markedly reduce the acute toxicity of gemcitabine.
