肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2012年
12期
831-834,837
,共5页
王聪仁%苏子剑%潘群雄%庄建良
王聰仁%囌子劍%潘群雄%莊建良
왕총인%소자검%반군웅%장건량
食管肿瘤%癌,鳞状细胞%CD24%预后
食管腫瘤%癌,鱗狀細胞%CD24%預後
식관종류%암,린상세포%CD24%예후
Esophageal neoplasms%Carcinoma,squamous cell%CD24%Prognosis
目的 检测CD24在食管鳞状细胞癌组织中表达的情况,探讨其与临床病理参数的关系及对预后的临床意义.方法 应用免疫组织化学EnVision法检测90例食管鳞状细胞癌组织中CD24的表达情况,分析CD24与食管鳞状细胞癌临床病理特征及预后的关系.结果 CD24在食管鳞状细胞癌组织中的阳性表达率明显高于癌旁组织(x2=0.832,P< 0.05).CD24在食管鳞状细胞癌中的阳性表达与患者的年龄、性别、有无脉管浸润、组织学分级无关(x2分别为0.741、0.361、0.930、8.858,均P>0.05),而与淋巴结转移(x2=12.349,P=0.000)、TNM分期(x2=10.804,P=0.005)和浸润深度(x2=13.94,P=0.007)呈正相关;不同CDu表达组(+、++、+++)之间的生存率差异有统计学意义,OR(95%CI)分别为2.105(61.022~ 69.273)、2.313(55.108~ 64.176)、1.286(32.388 ~ 37.429),CD24表达强阳性食管鳞状细胞癌患者的生存率明显低于CD24表达强度较低组.CD24浸润深度、淋巴结转移是影响食管鳞状细胞癌预后的独立因素.结论 CD24可能提示食管鳞状细胞癌发展的恶性进程,其高表达提示食管鳞状细胞癌患者预后不良.CD24有望成为一个新的相对独立的食管鳞状细胞癌预后预测指标.
目的 檢測CD24在食管鱗狀細胞癌組織中錶達的情況,探討其與臨床病理參數的關繫及對預後的臨床意義.方法 應用免疫組織化學EnVision法檢測90例食管鱗狀細胞癌組織中CD24的錶達情況,分析CD24與食管鱗狀細胞癌臨床病理特徵及預後的關繫.結果 CD24在食管鱗狀細胞癌組織中的暘性錶達率明顯高于癌徬組織(x2=0.832,P< 0.05).CD24在食管鱗狀細胞癌中的暘性錶達與患者的年齡、性彆、有無脈管浸潤、組織學分級無關(x2分彆為0.741、0.361、0.930、8.858,均P>0.05),而與淋巴結轉移(x2=12.349,P=0.000)、TNM分期(x2=10.804,P=0.005)和浸潤深度(x2=13.94,P=0.007)呈正相關;不同CDu錶達組(+、++、+++)之間的生存率差異有統計學意義,OR(95%CI)分彆為2.105(61.022~ 69.273)、2.313(55.108~ 64.176)、1.286(32.388 ~ 37.429),CD24錶達彊暘性食管鱗狀細胞癌患者的生存率明顯低于CD24錶達彊度較低組.CD24浸潤深度、淋巴結轉移是影響食管鱗狀細胞癌預後的獨立因素.結論 CD24可能提示食管鱗狀細胞癌髮展的噁性進程,其高錶達提示食管鱗狀細胞癌患者預後不良.CD24有望成為一箇新的相對獨立的食管鱗狀細胞癌預後預測指標.
목적 검측CD24재식관린상세포암조직중표체적정황,탐토기여림상병리삼수적관계급대예후적림상의의.방법 응용면역조직화학EnVision법검측90례식관린상세포암조직중CD24적표체정황,분석CD24여식관린상세포암림상병리특정급예후적관계.결과 CD24재식관린상세포암조직중적양성표체솔명현고우암방조직(x2=0.832,P< 0.05).CD24재식관린상세포암중적양성표체여환자적년령、성별、유무맥관침윤、조직학분급무관(x2분별위0.741、0.361、0.930、8.858,균P>0.05),이여림파결전이(x2=12.349,P=0.000)、TNM분기(x2=10.804,P=0.005)화침윤심도(x2=13.94,P=0.007)정정상관;불동CDu표체조(+、++、+++)지간적생존솔차이유통계학의의,OR(95%CI)분별위2.105(61.022~ 69.273)、2.313(55.108~ 64.176)、1.286(32.388 ~ 37.429),CD24표체강양성식관린상세포암환자적생존솔명현저우CD24표체강도교저조.CD24침윤심도、림파결전이시영향식관린상세포암예후적독립인소.결론 CD24가능제시식관린상세포암발전적악성진정,기고표체제시식관린상세포암환자예후불량.CD24유망성위일개신적상대독립적식관린상세포암예후예측지표.
Objective To study the significance of CD24 protein expression in esophageal squamous cell carcinoma and its relationship with clinical pathological parameters and clinical prognosis.Methods The expression of CD24 protein was studied in 90 esophageal squamous cell carcinoma samples by EnVision immunohistochemical analysis and to study relationship of CD24 with clinical pathological parameters and prognosis.Results The expression of CD24 in esophageal squamous cell carcinoma was significantly higher than that in adjacent normal tissue (x 2 =0.832,P < 0.05).The expression of CD24 was not related with the age of patien,sexuality and the histologic grade (x2 =0.741,0.361,0.930,8.858,all P > 0.05),but with clinical stage of the cance (x2 =10.804,P =0.005),lymph node metastasis (x2 =12.349,P =0.000) and depth of tumor invasion (x2 =13.94,P =0.007).Significant difference in survival between the different CD24 expression group,the OR (95 % CI) values were 2.105 (61.022-69.273),2.313 (55.108-64.176),1.286 (32.388-37.429),the survival of patients with strong expression of CD24 was inferior to that of weak expression of CD24,depth of tumor invasion and lymph node metastasis were independent prognostic factors of esophageal squamous cell carcinoma.Conclusion CD24 may be related to the malignant process of esophageal squamous cell carcinoma.Overexpression of CD24 indicates poor prognosis in esophageal squamous cell carcinoma patients.CD24 may become a new independent prognostic factor for esophageal squamous cell carcinoma.