CAJ | 학술논문

目的探讨促性腺激素释放激素激动剂在治疗子宫内膜异位症中的作用.方法将腹腔镜保守性手术后41例子宫内膜异位症患者随机分为两组:传统用量组(21例)术后给予达菲林3.75 mg,肌肉注射,每4周1次,连续6次,半量组(20例)术后给予达菲林1.9 mg,肌肉注射,每4周1次,连续6次.结果两组患者痛经症状均有不同程度减轻,两组患者至用药12周妇科检查盆腔触痛消失,所有患者肛门坠胀感缓解,传统用量组临床缓解率为87.1％,半量组为86.3％,差异无统计学意义(P＞0.05)；传统用量组21例患者B超检查复发率为4.8％,半量组为5％,差异无统计学意义(P＞0.05)；传统用量组21例患者78.6％患者出现明显的潮热、多汗等低雌激素症状,半量组20例患者治疗过程中未发现低雌激素症状,差异有统计学意义(P＜0.01).结论半量促性腺激素释放激素激动剂在缓解低雌激素症状是安全有效的,半量疗法能减轻促性腺激素释放激素激动剂的不良反应而不影响其疗效.
목적 탐토촉성선격소석방격소격동제재치료자궁내막이위증중적작용.방법 장복강경보수성수술후41례자궁내막이위증환자수궤분위량조:전통용량조(21례)술후급여체비림3.75 mg,기육주사,매4주1차,련속6차,반량조(20례)술후급여체비림1.9 mg,기육주사,매4주1차,련속6차.결과 량조환자통경증상균유불동정도감경,량조환자지용약12주부과검사분강촉통소실,소유환자항문추창감완해,전통용량조림상완해솔위87.1％,반량조위86.3％,차이무통계학의의(P＞0.05)；전통용량조21례환자B초검사복발솔위4.8％,반량조위5％,차이무통계학의의(P＞0.05)；전통용량조21례환자78.6％환자출현명현적조열、다한등저자격소증상,반량조20례환자치료과정중미발현저자격소증상,차이유통계학의의(P＜0.01).결론 반량촉성선격소석방격소격동제재완해저자격소증상시안전유효적,반량요법능감경촉성선격소석방격소격동제적불량반응이불영향기료효.
Objective To investigate the effect of half-dose GuRH-a on endometriosis.Methods Forty-one patients with endometriosis underwent laparoscopic conservative operation were randomly divided into traditional dose group(21cases),with intramuscular injection of diphereline 3.75 mg,once every four weeks for 6 times,and half-dose group,with intramuscular injection of diphereline 1.9 mg,once every four weeks for 6 times.Results The symptom of dysmenorrhea in both two groups relieved in different degrees.Twelve weeks after treatment,the patients received gynecologial examination and the tenderness in pelvic disappeared in both groups.Anal expansion relieved in most patients.The clinical remission rate of the traditional dose group was 87.1％,while that of the half-dose group was 86.3％,there was no significanct difference (P ＞ 0.05).Checked by type-B ultrasound,the recurrence rate of the traditional dose group was 4.8％,while that of the half-dose group was 5％,there was no significant difference (P ＞ 0.05).Obvious low estrogen symptoms like afternoon fever and hyperhidrosis occurred in 78.6％ of the traditional dose group,while no such symptoms occurred in the half-dose group,and there was significant difference (P ＜ 0.01).Conclusions It is safe and effective to use half-dose GuRH-a for treating endometriosis.The half-dose treatment method can obtain the same effect as the traditional dose treatment,and decrease the side effects.