中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
3期
10-12
,共3页
蔡劲%任大宏%黎民宇%赵妮妮%杨静%施茜
蔡勁%任大宏%黎民宇%趙妮妮%楊靜%施茜
채경%임대굉%려민우%조니니%양정%시천
口腔鳞状细胞癌%一氧化氮合酶%环氧化酶-2%血管内皮生长因子%免疫组化
口腔鱗狀細胞癌%一氧化氮閤酶%環氧化酶-2%血管內皮生長因子%免疫組化
구강린상세포암%일양화담합매%배양화매-2%혈관내피생장인자%면역조화
Oral squamous cell carcinoma%Carbon monoxide synthase%Cyclooxygenase-2%Vascular endothelial growth factor%Immunohistochemistry
目的 研究诱导型一氧化氮合酶(iNOS)、环氧化酶-2(COX-2)在口腔鳞状细胞癌组织中的表达,探讨它们与血管内皮生长因子(VEGF)的相互关系和临床意义.方法 应用免疫组化方法检测iNOS、COX-2、VEGF在54例口腔鳞癌组织中的表达,分析它们的表达情况以及各指标之间的相互关系.结果 iNOS、COX-2与VEGF在口腔鳞癌组织中蛋白阳性表达率分别为66.7％、55.6％、62.5％；iNOS、COX-2与VEGF的表达随着口腔癌病理分级及临床分期的上升而呈上升趋势(P＜0.05),且iNOS与VEGF、COX-2与VEGF呈正相关(P＜0.05).结论 iNOS、COX-2和VEGF在口腔鳞癌组织中均高表达,与口腔鳞癌的生物学行为密切相关,iNOS、COX-2参与VEGF促肿瘤血管生成.
目的 研究誘導型一氧化氮閤酶(iNOS)、環氧化酶-2(COX-2)在口腔鱗狀細胞癌組織中的錶達,探討它們與血管內皮生長因子(VEGF)的相互關繫和臨床意義.方法 應用免疫組化方法檢測iNOS、COX-2、VEGF在54例口腔鱗癌組織中的錶達,分析它們的錶達情況以及各指標之間的相互關繫.結果 iNOS、COX-2與VEGF在口腔鱗癌組織中蛋白暘性錶達率分彆為66.7％、55.6％、62.5％；iNOS、COX-2與VEGF的錶達隨著口腔癌病理分級及臨床分期的上升而呈上升趨勢(P＜0.05),且iNOS與VEGF、COX-2與VEGF呈正相關(P＜0.05).結論 iNOS、COX-2和VEGF在口腔鱗癌組織中均高錶達,與口腔鱗癌的生物學行為密切相關,iNOS、COX-2參與VEGF促腫瘤血管生成.
목적 연구유도형일양화담합매(iNOS)、배양화매-2(COX-2)재구강린상세포암조직중적표체,탐토타문여혈관내피생장인자(VEGF)적상호관계화림상의의.방법 응용면역조화방법검측iNOS、COX-2、VEGF재54례구강린암조직중적표체,분석타문적표체정황이급각지표지간적상호관계.결과 iNOS、COX-2여VEGF재구강린암조직중단백양성표체솔분별위66.7％、55.6％、62.5％；iNOS、COX-2여VEGF적표체수착구강암병리분급급림상분기적상승이정상승추세(P＜0.05),차iNOS여VEGF、COX-2여VEGF정정상관(P＜0.05).결론 iNOS、COX-2화VEGF재구강린암조직중균고표체,여구강린암적생물학행위밀절상관,iNOS、COX-2삼여VEGF촉종류혈관생성.
Objective To investigate the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)protein in oral squamous cell carcinoma tissue,and to explore relationship and vascular endothelial growth factor (VEGF) of them.Methods The expression of iNOS,COX-2 and VEGF in 54 cases of oral mucosa squamous cell carcinoma tissue were detected by immunohistochemistry SP staining.And its correlation to clinicopathologic features were analyzed.Results The positive expression rates of iNOS,COX-2 and VEGF were 66.7％,55.6％,62.5％ respectively.The positive expression of iNOS,COX-2 and VEGF was correlated with pathological grade,TNM stage and tumor recurrence (P ＜ 0.05).There were positive correlations between the expression of iNOS and VEGF,COX-2 and VEGF(P ＜ 0.05).Conclusions The expression of iNOS,COX-2 and VEGF are both higher,they are closely correlated to biological action of oral carcinoma,iNOS,COX-2 participate in VEGF promote the tumor angiogenesis.
