CAJ | 학술논문

目的探讨急性加重期慢性阻塞性肺疾病(COPD)合并持续喘息与痰真菌培养阳性之间的相关性.方法收集2008年10月至2011年12月于沈阳医学院奉天医院呼吸科住院的急性加重期COPD患者的病例资料,进行回顾性分析.结果共收集到符合入选标准的COPD持续喘息组患者42例,COPD非喘息组患者40例.持续喘息组中38例(90.5％)痰真菌培养阳性,非喘息组中12例(30.0％)阳性,两组比较差异有统计学意义(P＜0.01).而在真菌的菌种构成方面,持续喘息组痰真菌阳性患者中曲霉分离率为34.2％(13/38),非喘息组患者中未检出曲霉,曲霉在两组中分布差异有统计学意义(P＜0.05).持续喘息组抗真菌治疗后症状缓解率显著高于未抗真菌治疗者(85.2％比45.5％,P＜0.05).结论急性加重期COPD合并持续喘息与真菌,特别是曲霉在气道内定植感染有关.
목적 탐토급성가중기만성조새성폐질병(COPD)합병지속천식여담진균배양양성지간적상관성.방법 수집2008년10월지2011년12월우침양의학원봉천의원호흡과주원적급성가중기COPD환자적병례자료,진행회고성분석.결과 공수집도부합입선표준적COPD지속천식조환자42례,COPD비천식조환자40례.지속천식조중38례(90.5％)담진균배양양성,비천식조중12례(30.0％)양성,량조비교차이유통계학의의(P＜0.01).이재진균적균충구성방면,지속천식조담진균양성환자중곡매분리솔위34.2％(13/38),비천식조환자중미검출곡매,곡매재량조중분포차이유통계학의의(P＜0.05).지속천식조항진균치료후증상완해솔현저고우미항진균치료자(85.2％비45.5％,P＜0.05).결론 급성가중기COPD합병지속천식여진균,특별시곡매재기도내정식감염유관.
Objective To investigate the correlation between persistent wheezing and positive result of sputum fungal culture in patients with chronic obstructive pulmonary disease(COPD).Methods The COPD patients who hospitalized in the respiratory department from October 2008 to December 2011were analyzed retrospectively.Results Forty-two cases were enrolled in the persistent wheezing group and 40 cases in the non-wheezing group.In the wheezing group,sputum fungal culture revealed positive yield in 38 cases (90.5％)while Aspergillus were isolated in 13 cases(34.2％).In the non-wheezing group,sputum fungal culture revealed only 12 cases(30.0％) positive,and none of which were Aspergillus positive.Aspergillus distributions in the two groups were significantly different (P ＜ 0.05).There was also significant difference in the positive result of sputum fungal culture (P ＜ 0.01).In the wheezing group,the patients with antifungal treatment showed better prognosis than those without antifungal treatment(85.2％ vs 45.5％,P ＜ 0.05).Conclusions The persistent wheezing in the patients with COPD is correlated with the fungi,especially Aspergillus airway colonization.