中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
6期
26-28
,共3页
许祯杰%徐风亮%徐日%徐延峰
許禎傑%徐風亮%徐日%徐延峰
허정걸%서풍량%서일%서연봉
卵巢癌%血清肿瘤标记物%彩色多普勒超声%联合检查
卵巢癌%血清腫瘤標記物%綵色多普勒超聲%聯閤檢查
란소암%혈청종류표기물%채색다보륵초성%연합검사
Ovarian cancer%Serum tumor makers%Color Doppler ultrasound%Combined diagnosis
目的 探讨血清肿瘤标记物糖类抗原125(CA125)、环氧化酶-1(COX-1)联合彩色多普勒超声(经阴道超声、经腹部超声)诊断卵巢癌的临床应用价值.方法 选取卵巢恶性肿瘤97例(卵巢癌组)、卵巢良性肿瘤101例(卵巢良性肿瘤组)为研究对象,均经术后病理或穿刺活检证实,全部有血清肿瘤标记物、彩色多普勒超声(经阴道超声、经腹部超声)检查资料,将各项检查资料与病理对照进行回顾性统计,分析各项检查的优、缺点.结果 CA125诊断卵巢癌的敏感性为75.3％ (73/97),特异性为92.1％(93/101),准确性为83.8％(166/198)；COX-1敏感性为48.5％(47/97),特异性为93.1％(94/101),准确性为71.2％(141/198);经阴道超声敏感性为86.6％(84/97),特异性为94.1％(95/101),准确性为90.4％(179/198)；经腹部超声敏感性为82.5％(80/97),特异性为91.1％(92/101),准确性为86.9％(172/198)；联合检查的敏感性为96.9％(94/97),特异性为89.1％(90/101),准确性为92.9％(184/198).结论 联合检查可显著提高卵巢癌诊断的敏感性,减少漏诊率,具有重要的临床应用价值.
目的 探討血清腫瘤標記物糖類抗原125(CA125)、環氧化酶-1(COX-1)聯閤綵色多普勒超聲(經陰道超聲、經腹部超聲)診斷卵巢癌的臨床應用價值.方法 選取卵巢噁性腫瘤97例(卵巢癌組)、卵巢良性腫瘤101例(卵巢良性腫瘤組)為研究對象,均經術後病理或穿刺活檢證實,全部有血清腫瘤標記物、綵色多普勒超聲(經陰道超聲、經腹部超聲)檢查資料,將各項檢查資料與病理對照進行迴顧性統計,分析各項檢查的優、缺點.結果 CA125診斷卵巢癌的敏感性為75.3％ (73/97),特異性為92.1％(93/101),準確性為83.8％(166/198)；COX-1敏感性為48.5％(47/97),特異性為93.1％(94/101),準確性為71.2％(141/198);經陰道超聲敏感性為86.6％(84/97),特異性為94.1％(95/101),準確性為90.4％(179/198)；經腹部超聲敏感性為82.5％(80/97),特異性為91.1％(92/101),準確性為86.9％(172/198)；聯閤檢查的敏感性為96.9％(94/97),特異性為89.1％(90/101),準確性為92.9％(184/198).結論 聯閤檢查可顯著提高卵巢癌診斷的敏感性,減少漏診率,具有重要的臨床應用價值.
목적 탐토혈청종류표기물당류항원125(CA125)、배양화매-1(COX-1)연합채색다보륵초성(경음도초성、경복부초성)진단란소암적림상응용개치.방법 선취란소악성종류97례(란소암조)、란소량성종류101례(란소량성종류조)위연구대상,균경술후병리혹천자활검증실,전부유혈청종류표기물、채색다보륵초성(경음도초성、경복부초성)검사자료,장각항검사자료여병리대조진행회고성통계,분석각항검사적우、결점.결과 CA125진단란소암적민감성위75.3％ (73/97),특이성위92.1％(93/101),준학성위83.8％(166/198)；COX-1민감성위48.5％(47/97),특이성위93.1％(94/101),준학성위71.2％(141/198);경음도초성민감성위86.6％(84/97),특이성위94.1％(95/101),준학성위90.4％(179/198)；경복부초성민감성위82.5％(80/97),특이성위91.1％(92/101),준학성위86.9％(172/198)；연합검사적민감성위96.9％(94/97),특이성위89.1％(90/101),준학성위92.9％(184/198).결론 연합검사가현저제고란소암진단적민감성,감소루진솔,구유중요적림상응용개치.
Objective To investigate the clinical value of serum tumor makers CA125,COX-1 combined with the color Doppler ultrasound in diagnosis of ovarian cancer.Methods Collected materials of 97 patients with malignant tumor of ovary(ovarian cancer group) and 101 patients with benign ovarian cancer(contrast group).All of them were detected by the postoperative pathology or puncture biopsy to get the data of the serum tumor maker CA125 and the color Doppler ultrasound.Compared with retrospective pathology to analyze the advantages and disadvantages of the detections.Results The sensitivity of CA125 was 75.3％ (73/97),specificity 92.1％ (93/101),accuracy 83.8％ (166/198) ;The sensitivity of COX-1 was 48.5％ (47/97),specificity 93.1％ (94/101),accuracy 71.2％ (141/198) ; The sensitivity of transvaginal ultrasound was 86.6％ (84/97),specificity 94.1％ (95/101),accuracy 90.4％ (179/198) ; The sensitivity of abdominal ultrasound was 82.5％ (80/97),specificity 91.1％ (92/101),accuracy 86.9％ (172/198) ; The sensitivity of the combined detections was 96.9％ (94/97),specificity 89.1％ (90/101),accuracy 92.9％ (184/198).Conclusions Combined diagnosis is an effective way to improve the sensitivity of the ovarian cancer with reliable guidance significance.
