中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
6期
45-47
,共3页
张丽卿%王建宝%郭任维%李建兰
張麗卿%王建寶%郭任維%李建蘭
장려경%왕건보%곽임유%리건란
系统性红斑狼疮%肺动脉高压%雷诺现象%易患因素
繫統性紅斑狼瘡%肺動脈高壓%雷諾現象%易患因素
계통성홍반랑창%폐동맥고압%뢰낙현상%역환인소
Systemic lupus erythematosus%Pulmonary hypertention%Raynaud's phenomenon%Risk factors
目的 探讨系统性红斑狼疮合并肺动脉高压患者的临床特点及危险因素.方法 收集135例系统性红斑狼疮患者,按是否合并肺动脉高压进行分组,对其临床症状、实验室指标、系统性红斑狼疮病情活动评分等进行回顾性分析,并采用Logistic回归分析方法进行分析.结果 单因素分析显示:系统性红斑狼疮合并肺动脉高压者血清ACL、抗Sm抗体、抗RNP抗体阳性率明显高于无肺动脉高压组(P值分别为0.000,0.000,0.000)；系统性红斑狼疮并肺动脉高压组雷诺现象、心包积液、肺栓塞、慢性肺间质病变的发生明显高于无PAH组(P值分别为0.000,0.000,0.001,0.000).将上述因素按ENTER法引入,进一步行多因素Logistic回归分析,结果显示:系统性红斑狼疮合并肺动脉高压患者雷诺现象、心包炎、慢性肺间质病变、ACL阳性明显高于无PAH组(P值分别为0.002,0.005,0.010,0.021).结论 系统性红斑狼疮患者雷诺现象、慢性肺间质病变、心包炎、ACL阳性是肺动脉高压发生的独立危险因素,对于具有这些危险因素的患者应尽早进行心脏彩色多普勒超声检查,利于PAH早期诊断.
目的 探討繫統性紅斑狼瘡閤併肺動脈高壓患者的臨床特點及危險因素.方法 收集135例繫統性紅斑狼瘡患者,按是否閤併肺動脈高壓進行分組,對其臨床癥狀、實驗室指標、繫統性紅斑狼瘡病情活動評分等進行迴顧性分析,併採用Logistic迴歸分析方法進行分析.結果 單因素分析顯示:繫統性紅斑狼瘡閤併肺動脈高壓者血清ACL、抗Sm抗體、抗RNP抗體暘性率明顯高于無肺動脈高壓組(P值分彆為0.000,0.000,0.000)；繫統性紅斑狼瘡併肺動脈高壓組雷諾現象、心包積液、肺栓塞、慢性肺間質病變的髮生明顯高于無PAH組(P值分彆為0.000,0.000,0.001,0.000).將上述因素按ENTER法引入,進一步行多因素Logistic迴歸分析,結果顯示:繫統性紅斑狼瘡閤併肺動脈高壓患者雷諾現象、心包炎、慢性肺間質病變、ACL暘性明顯高于無PAH組(P值分彆為0.002,0.005,0.010,0.021).結論 繫統性紅斑狼瘡患者雷諾現象、慢性肺間質病變、心包炎、ACL暘性是肺動脈高壓髮生的獨立危險因素,對于具有這些危險因素的患者應儘早進行心髒綵色多普勒超聲檢查,利于PAH早期診斷.
목적 탐토계통성홍반랑창합병폐동맥고압환자적림상특점급위험인소.방법 수집135례계통성홍반랑창환자,안시부합병폐동맥고압진행분조,대기림상증상、실험실지표、계통성홍반랑창병정활동평분등진행회고성분석,병채용Logistic회귀분석방법진행분석.결과 단인소분석현시:계통성홍반랑창합병폐동맥고압자혈청ACL、항Sm항체、항RNP항체양성솔명현고우무폐동맥고압조(P치분별위0.000,0.000,0.000)；계통성홍반랑창병폐동맥고압조뢰낙현상、심포적액、폐전새、만성폐간질병변적발생명현고우무PAH조(P치분별위0.000,0.000,0.001,0.000).장상술인소안ENTER법인입,진일보행다인소Logistic회귀분석,결과현시:계통성홍반랑창합병폐동맥고압환자뢰낙현상、심포염、만성폐간질병변、ACL양성명현고우무PAH조(P치분별위0.002,0.005,0.010,0.021).결론 계통성홍반랑창환자뢰낙현상、만성폐간질병변、심포염、ACL양성시폐동맥고압발생적독립위험인소,대우구유저사위험인소적환자응진조진행심장채색다보륵초성검사,리우PAH조기진단.
Objective To investigate clinical characteristics and risk factors of the patients with systemic lupus erythematosus(SLE) combined pulmonary hypertension(PAH).Methods One hundred and thirty-five cases with SLE were divided into two groups by with or without PAH,clinical symptoms,laboratory parameters,SLE disease activity score were retrospective analysis by logistic regression analysis method.Results Single factor analysis showed the patients with SLE and PAH had higher positive rate of ACL,anti-Smith antibody,anti-RNP antibody in their serums than those with SLE (P value was 0.000,0.000,0.000 respectively),Raynaud's phenomenon(RP),pericardial effusion,intestinal lung disease(ILD),PTE were more in patients with SLE and PAH than in those with SLE(P value was 0.000,0.000,0.000,0.001 respectively).Multivariate analysis showed RP,pericardial effusion,ILD and positive ACL were significantly more in patients with SLE and PAH than in those with SLE(P value was 0.002,0.005,0.010,0.021 respectively).Conclusions RP,pericardial effusion,ILD and positive ACL are independent risk factors in the onset of PAH with SLE.Cardiac color doppler ultrasonography in patients with these risk factors should be carried out as soon as possible.
