CAJ | 학술논문

目的探讨经支气管镜局部灌注两性霉素B治疗肺部真菌感染的疗效.方法选择22例确诊肺部真菌感染的患者,随机分为两组:治疗组11例全身应用伏立康唑(4 mg/kg,每12小时给药1次)联合给予经支气管镜灌洗后,两性霉素B 25 mg+生理盐水10 ml局部保留灌注治疗；对照组11例全身应用伏立康唑(4mg/kg,每12小时给药1次),维持至治疗结束.结果治疗组有效率为81.8％,明显高于对照组的54.5％,差异有统计学意义(P＜0.05),且无明显不良反应.结论经支气管镜肺泡灌注两性霉素B治疗肺部真菌感染安全、疗效好、疗程短、经济.
목적 탐토경지기관경국부관주량성매소B치료폐부진균감염적료효.방법 선택22례학진폐부진균감염적환자,수궤분위량조:치료조11례전신응용복립강서(4 mg/kg,매12소시급약1차)연합급여경지기관경관세후,량성매소B 25 mg+생리염수10 ml국부보류관주치료；대조조11례전신응용복립강서(4mg/kg,매12소시급약1차),유지지치료결속.결과 치료조유효솔위81.8％,명현고우대조조적54.5％,차이유통계학의의(P＜0.05),차무명현불량반응.결론 경지기관경폐포관주량성매소B치료폐부진균감염안전、료효호、료정단、경제.
Objective To evaluate the efficacy of trans-bronchoscope local perfusion of amphotericin B on the treatment of pulmonary fungal infection.Methods Twenty-two patients with pulmonary fungal infection were randomly divided into two groups:Patients in treatment group (11 cases) were given systemic application of voriconazole (4 mg/kg,once every 12 hours) combined with bronchoscope local perfusion amphotericin B 25 mg and 10 ml physiological saline; Patients in control group(11 cases) were given systemic application of voriconazole (4 mg/kg,once every 12 hours).Results The effective rate of treatment group (81.8％) was higher than that of control group (54.5％),the difference was statistically significant (P ＜ 0.05),and there was no significant adverse reactions occurred.Conclusions Bronchoscope alveolar perfusion of amphotericin B in the treatment of pulmonary fungal infection is safe and effective,economic and has short course.