CAJ | 학술논문

目的探讨急性进展性脑梗死患者血浆纤维蛋白原及D-二聚体的含量变化及临床价值.方法回顾性分析96例急性脑梗死患者的临床资料,根据疾病进展与否将患者分为进展组40例和非进展组56例,并选择我院40例健康体检者纳入对照组.检测三组研究对象血浆纤维蛋白原及D-二聚体含量,动态比较两组脑梗死患者神经功能缺损评分的变化.结果两组急性脑梗死患者的血浆纤维蛋白原及D-二聚体水平均显著高于对照组(P＜0.05),D-二聚体阳性率均明显高于对照组(P＜0.05),进展组患者上述指标均明显高于非进展组,差异有统计学意义(P＜0.05)；病程第7天及第21天进展组患者SSS评分均低于非进展组,差异均有统计学意义(P＜0.05).结论急性进展性脑梗死患者血浆纤维蛋白原及D-二聚体水平可出现明显升高,并与病情进展的呈密切相关.
목적 탐토급성진전성뇌경사환자혈장섬유단백원급D-이취체적함량변화급림상개치.방법 회고성분석96례급성뇌경사환자적림상자료,근거질병진전여부장환자분위진전조40례화비진전조56례,병선택아원40례건강체검자납입대조조.검측삼조연구대상혈장섬유단백원급D-이취체함량,동태비교량조뇌경사환자신경공능결손평분적변화.결과 량조급성뇌경사환자적혈장섬유단백원급D-이취체수평균현저고우대조조(P＜0.05),D-이취체양성솔균명현고우대조조(P＜0.05),진전조환자상술지표균명현고우비진전조,차이유통계학의의(P＜0.05)；병정제7천급제21천진전조환자SSS평분균저우비진전조,차이균유통계학의의(P＜0.05).결론 급성진전성뇌경사환자혈장섬유단백원급D-이취체수평가출현명현승고,병여병정진전적정밀절상관.
Objective To investigate the clinical value of plasma fibrinogen and D-dimer determination patients with acute progressive cerebral infarction.Methods Ninety-six patients with acute progressive cerebral infarction (APCI) were divided into the progressive group (40 cases) and non-progressive group (56 cases) according to the disease progression or not,and 40 healthy subjects were included as the control group.The levels of plasma fibrinogen and D-dimer dynamic in the three groups were detected,and the cerebral infarction nerve function deficit score changes between the two groups were compared.Results The levels of fibrinogen and D-dimer were significantly higher in patients with APCI than those in control group (P ＜ 0.05),and the D-dimer positive rate was significantly higher (P ＜ 0.05),and those above indicators in progressive group was significantly higher than those in the non-progressive group,the differences were statistically significant (P ＜ 0.05) ; On the 7th day and 21st day,the SSS scores were lower than those in the non-progressive group,the differences were statistically significant(P ＜0.05).Conclusions The plasma fibrinogen and D-dimer levels significantly increase in patients with APCI,and they are closely correlated with the progression of disease.