CAJ | 학술논문

目的探讨老年高血压患者微量白蛋白尿与脂联素及颈动脉粥样硬化的关系.方法老年高血压患者80例[根据尿微量白蛋白分为高血压微量蛋白尿组(MAU组,n=40)和高血压正常蛋白尿组(NMAU组,n=40)]及健康对照组40例.测定各组尿微量白蛋白、脂联素(APN)等,彩色超声检测颈动脉内膜-中层厚度(IMT)及粥样斑块,并进行比较.结果 MAU组的ANP低于NMAU组及对照组(P均＜0.05),IMT高于NMAU组及对照组(P均＜0.05),老年高血压患者微量白蛋白尿与APN呈负相关(P＜0.05),与IMT呈正相关(P＜0.05).结论老年高血压患者血清脂联素及颈动脉粥样硬化与微量白蛋白尿的发生密切相关.
목적 탐토노년고혈압환자미량백단백뇨여지련소급경동맥죽양경화적관계.방법 노년고혈압환자80례[근거뇨미량백단백분위고혈압미량단백뇨조(MAU조,n=40)화고혈압정상단백뇨조(NMAU조,n=40)]급건강대조조40례.측정각조뇨미량백단백、지련소(APN)등,채색초성검측경동맥내막-중층후도(IMT)급죽양반괴,병진행비교.결과 MAU조적ANP저우NMAU조급대조조(P균＜0.05),IMT고우NMAU조급대조조(P균＜0.05),노년고혈압환자미량백단백뇨여APN정부상관(P＜0.05),여IMT정정상관(P＜0.05).결론 노년고혈압환자혈청지련소급경동맥죽양경화여미량백단백뇨적발생밀절상관.
Objective To investigate the relationship among the degree of carotid artery atherosclerosis,adiponectin (APN)and microalbuminuria (MAU)in aged patients with essential hypertension.Methods Consecutive 80 aged patients with essential hypertension were divided into two groups according to the MAU level:the group of patients with MAU (n =40) and the group of patients with normoalbuminuria (NMAU,n =40).And 40 healthy people were enrolled as healthy control group (n =40) MAU,APN and carotid artery intimamedia thickness (IMT) were determined in three groups.Results The levels of APN in MAU group were lower than those in NMAU group and healthy control group (P ＜ 0.05) ; The levels of IMT in MAU group were thinker than those in NMAU group and healthy control group (P ＜ 0.05) ; There were correlations of level of MAU and concentration of APN,IMT in aged patients with EH (P ＜ 0.05).Conclusions The concentration of serum adiponection and carotid artery atherosclerosis are closely correlated with MAU in aged patients with essential hypertension.