中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
23期
97-99
,共3页
郝晓慧%岳梅枝%张玉芝%吴远佳
郝曉慧%嶽梅枝%張玉芝%吳遠佳
학효혜%악매지%장옥지%오원가
原发性高血压%颈动脉粥样硬化%白介素-6%高敏C反应蛋白
原髮性高血壓%頸動脈粥樣硬化%白介素-6%高敏C反應蛋白
원발성고혈압%경동맥죽양경화%백개소-6%고민C반응단백
Primary hypertension%Atherosclersis%Interleukin-6%High-sensitivity C-reactive protein
目的 探讨原发性高血压患者血清白介素-6(IL-6)、高敏C反应蛋白(hs-CRP)与颈动脉粥样硬化程度的关系.方法 选择原发性高血压患者120例,按颈动脉超声检测结果分为内膜增厚组、斑块形成组和管腔狭窄组,测定三组患者的血清IL-6和hs-CRP水平,进行统计学分析.结果 颈动脉粥样硬化程度越严重,IL-6和血清hs-CRP水平越高,三组间比较差异有统计学意义(P＜0.05).结论 原发性高血压患者血清IL-6和hs-CRP水平与动脉粥样硬化程度关系密切,原发性高血压患者IL-6、hs-CRP浓度与颈动脉内膜中层厚度(IMT)呈正相关关系(P＜0.01).适当降低血清IL-6和hs-CRP,可防止动脉粥样硬化进展,减轻高血压靶器官损害.
目的 探討原髮性高血壓患者血清白介素-6(IL-6)、高敏C反應蛋白(hs-CRP)與頸動脈粥樣硬化程度的關繫.方法 選擇原髮性高血壓患者120例,按頸動脈超聲檢測結果分為內膜增厚組、斑塊形成組和管腔狹窄組,測定三組患者的血清IL-6和hs-CRP水平,進行統計學分析.結果 頸動脈粥樣硬化程度越嚴重,IL-6和血清hs-CRP水平越高,三組間比較差異有統計學意義(P＜0.05).結論 原髮性高血壓患者血清IL-6和hs-CRP水平與動脈粥樣硬化程度關繫密切,原髮性高血壓患者IL-6、hs-CRP濃度與頸動脈內膜中層厚度(IMT)呈正相關關繫(P＜0.01).適噹降低血清IL-6和hs-CRP,可防止動脈粥樣硬化進展,減輕高血壓靶器官損害.
목적 탐토원발성고혈압환자혈청백개소-6(IL-6)、고민C반응단백(hs-CRP)여경동맥죽양경화정도적관계.방법 선택원발성고혈압환자120례,안경동맥초성검측결과분위내막증후조、반괴형성조화관강협착조,측정삼조환자적혈청IL-6화hs-CRP수평,진행통계학분석.결과 경동맥죽양경화정도월엄중,IL-6화혈청hs-CRP수평월고,삼조간비교차이유통계학의의(P＜0.05).결론 원발성고혈압환자혈청IL-6화hs-CRP수평여동맥죽양경화정도관계밀절,원발성고혈압환자IL-6、hs-CRP농도여경동맥내막중층후도(IMT)정정상관관계(P＜0.01).괄당강저혈청IL-6화hs-CRP,가방지동맥죽양경화진전,감경고혈압파기관손해.
Objective To investigate the correlation of serum interleukin-6(IL-6) and high-sensitivity protein (hs-CRP) with carotid atherosclerosis in patients with primary hypertension.Methods One hundred and twenty patients with primary hypertension whose CCAs were detected by ultrasound were divided into increased innermembrance group,atheroma group and narrow luminal diameter group.Their serum IL-6 and high-sensitivity protein levels were measured and compared.Results Those with higher serum IL-6 and higher serum hs-CRP levels showed more severe carotid atherosclerosis.There was significant difference among the three groups (P ＜ 0.05,P ＜ 0.01).Conclusions Serum IL-6 and hs-CRP might be closely related to the atherosclerosis in patients with hypertension.There was positive relativity between the serum IL-6 and hs-CRP and intima media thickness (IMT).It might be concluded that lower serum IL-6 and hs-CRP levels could prevent the progression of atherosclerosis,relieve the organ damage induced by hypertension.
