CAJ | 학술논문

目的探讨乌苯美司对中老年不愿静脉化疗的多发性骨髓瘤患者的疗效和免疫功能的影响.方法将患者随机分为两组,对照组应用MPT方案,治疗组应用MPT和乌苯美司片,2个周期后评价疗效和T细胞亚群.结果两组CD4+T细胞比例治疗前均较治疗后低;CD8+T细胞比例治疗前均较治疗后高,差异均有统计学意义.两组之间治疗前后比较差异无统计学意义.治疗组有效率高于对照组,差异有统计学意义.结论乌苯美司联合化疗可提高化疗有效率.
목적 탐토오분미사대중노년불원정맥화료적다발성골수류환자적료효화면역공능적영향.방법 장환자수궤분위량조,대조조응용MPT방안,치료조응용MPT화오분미사편,2개주기후평개료효화T세포아군.결과 량조CD4+T세포비례치료전균교치료후저;CD8+T세포비례치료전균교치료후고,차이균유통계학의의.량조지간치료전후비교차이무통계학의의.치료조유효솔고우대조조,차이유통계학의의.결론 오분미사연합화료가제고화료유효솔.
Objective To investigate the effect and immune function of ubenimex in the treatment of middle-aged and aged patients with multiple myeloma who were unwilling to receive intravenous chemotherapy.Methods Patients were divided into two groups randomly,control group applied MPT scheme,treatment group applied MPT and ubenimex.Efficacy and T cell subgroup were evaluated after two cycles.Results Both group of CD4 + T cell percentage were lower after treatment than before treatment,CD8 + T cell percentage were higher after treatment than before treatment,the differences were statistically significant.There was no significant difference between the two groups before and after treatment.The effective rate of treatment group was higher than that of control group,the difference was statistically significant.Conclusions Ubenimex combined with chemotherapy can improve the treatment efficiency.