中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2013年
24期
5-7
,共3页
慢性肺源性心脏病%无创正压通气%纳洛酮%超敏C-反应蛋白%N-末端B型脑钠肽前体%内皮素-1
慢性肺源性心髒病%無創正壓通氣%納洛酮%超敏C-反應蛋白%N-末耑B型腦鈉肽前體%內皮素-1
만성폐원성심장병%무창정압통기%납락동%초민C-반응단백%N-말단B형뇌납태전체%내피소-1
Chronic pulmonary heart disease%Noninvasive BiPAP%Naloxone%High sensitive C-reactive protein%N-terminal pro-brain natriuretic peptide%Endothelin-1
目的 探讨无创正压通气联合纳洛酮对慢性肺源性心脏病(肺心病)急性加重期患者超敏C-反应蛋白(hs-CRP)、N-末端B型脑钠肽前体(NT-proBNP)和内皮素-1(ET-1)的影响.方法 将106例肺心病急性加重期患者随机分为两组,每组53例.对照组采用常规治疗,观察组在常规治疗的基础上加用无创正压通气联合纳洛酮.治疗10 d后观察疗效.测定治疗前后患者血浆hs-CRP、NT-proBNP和ET-1.结果 两组患者治疗后平均肺动脉压(MPAP)均明显下降,并且观察组比对照组下降更明显(P＜0.05).两组在治疗后患者血浆hs-CRP、NT-proBNP和ET-1均有明显下降,与对照组比较,观察组治疗后下降更明显(P＜0.05).结论 无创正压通气联合纳洛酮可以明显减少肺心病急性加重期患者hs-CRP、NT-proBNP和ET-1的表达.
目的 探討無創正壓通氣聯閤納洛酮對慢性肺源性心髒病(肺心病)急性加重期患者超敏C-反應蛋白(hs-CRP)、N-末耑B型腦鈉肽前體(NT-proBNP)和內皮素-1(ET-1)的影響.方法 將106例肺心病急性加重期患者隨機分為兩組,每組53例.對照組採用常規治療,觀察組在常規治療的基礎上加用無創正壓通氣聯閤納洛酮.治療10 d後觀察療效.測定治療前後患者血漿hs-CRP、NT-proBNP和ET-1.結果 兩組患者治療後平均肺動脈壓(MPAP)均明顯下降,併且觀察組比對照組下降更明顯(P＜0.05).兩組在治療後患者血漿hs-CRP、NT-proBNP和ET-1均有明顯下降,與對照組比較,觀察組治療後下降更明顯(P＜0.05).結論 無創正壓通氣聯閤納洛酮可以明顯減少肺心病急性加重期患者hs-CRP、NT-proBNP和ET-1的錶達.
목적 탐토무창정압통기연합납락동대만성폐원성심장병(폐심병)급성가중기환자초민C-반응단백(hs-CRP)、N-말단B형뇌납태전체(NT-proBNP)화내피소-1(ET-1)적영향.방법 장106례폐심병급성가중기환자수궤분위량조,매조53례.대조조채용상규치료,관찰조재상규치료적기출상가용무창정압통기연합납락동.치료10 d후관찰료효.측정치료전후환자혈장hs-CRP、NT-proBNP화ET-1.결과 량조환자치료후평균폐동맥압(MPAP)균명현하강,병차관찰조비대조조하강경명현(P＜0.05).량조재치료후환자혈장hs-CRP、NT-proBNP화ET-1균유명현하강,여대조조비교,관찰조치료후하강경명현(P＜0.05).결론 무창정압통기연합납락동가이명현감소폐심병급성가중기환자hs-CRP、NT-proBNP화ET-1적표체.
Objective To investigate the effect of noninvasive BiPAP combined with naloxone on plasma high sensitivity C-reactive protein(hs-CRP),N-terminal pro-B-type brain natriuretic peptide(NT-proBNP) and endothelin(ET-1) levels in patients with acute exacerbation of pulmonary heart disease.Methods One hundred and six patients with severe bronchial asthma were randomly divided into two groups,the observation group and the control group,with 53 cases in each group.Control group was given conventional treatment,while in observation group,based on conventional treatment,noninvasive positive pressure ventilation combined with naloxone was given.The effects were observed after 10 days of treatment.The mean pulmonary arterial pressure(MPAP),plasma hs-CRP,NT-proBNP and ET-1 were detected before and after treatment.Results MPAP in both groups decreased obviously after treatment,and MPAP of observation group was lower than that of the control group (P ＜ 0.05).Plasma hs-CRP,NT-proBNP and ET-1 levels significantly reduced in both groups after treatment,the observation group decreased more significantly,compared with the control group after treatment (P ＜ 0.05).Conclusions Noninvasive BiPAP combined with naloxone can decrease the expression of plasma hs-CRP,NT-proBNP and ET-1 levels in patients with acute exacerbation of pulpmonary heart disease.
