CAJ | 학술논문

目的观察替吉奥单药治疗老年晚期及复发性胃癌的近期疗效及不良反应.方法 56例老年晚期及复发性胃癌患者,均口服单药替吉奥,80 mg/(m2·d),2次/d,早晚饭后半小时口服,连服14 d,停药7d,3周为1个周期.至少服用2个周期后评价疗效及不良反应.结果本研究56例,完全缓解2例,部分缓解19例,总有效率为37.5％;疾病稳定19例,疾病进展16例,临床受益率为60.6％.生活质量改善:化疗后KPS评分改善23例,占41.1％;稳定27例,占48.2％.主要不良反应为白细胞减少,红细胞减少,恶心、呕吐,腹泻,皮肤色素沉着,皮疹等.结论替吉奥单药治疗老年晚期及复发性胃癌疗效较好,不良反应能耐受,值得临床推广应用.
목적 관찰체길오단약치료노년만기급복발성위암적근기료효급불량반응.방법 56례노년만기급복발성위암환자,균구복단약체길오,80 mg/(m2·d),2차/d,조만반후반소시구복,련복14 d,정약7d,3주위1개주기.지소복용2개주기후평개료효급불량반응.결과본연구56례,완전완해2례,부분완해19례,총유효솔위37.5％;질병은정19례,질병진전16례,림상수익솔위60.6％.생활질량개선:화료후KPS평분개선23례,점41.1％;은정27례,점48.2％.주요불량반응위백세포감소,홍세포감소,악심、구토,복사,피부색소침착,피진등.결론체길오단약치료노년만기급복발성위암료효교호,불량반응능내수,치득림상추엄응용.
Objective To observe the short-term efficacy and toxicity of titanium silicate(S-1) in the treatment of elderly patients with advanced and recurrent gastric cancer.Methods Fifty-six elderly patients with advanced and recurrent gastric cancer were given S-1 80 mg/(m2 · d)orally,2 times/d for 14 days,then drug with drawal for 7 days,3 weeks for a cycle.Then the efficacy and toxicity after 2 cycles of treatment was evaluated.Results Fifty-six patients can be evaluated the efficacy.CR in 2 cases and PR in 19 cases,the overall response rate was 37.5％ ; SD in 19 cases and PD in 16 cases,the disease control rate was 60.6％.The quality of life improved in 23 patients(41.1％),stabled in 27 patients(48.2％).The main adverse reactions were leukopenia,aglobulism,nausea and vomiting,diarrhea,skin pigmentation and rash.Conclusions S-1 in the treatment of elderly patients with advanced and recurrent gastric cancer has good effect,and the adverse reactions can be tolerated,so is worthy of promotion.