中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
1期
23-24
,共2页
心房颤动%辛伐他汀%胺碘酮%C-反应蛋白
心房顫動%辛伐他汀%胺碘酮%C-反應蛋白
심방전동%신벌타정%알전동%C-반응단백
Atrial fibrillation%Simvastatin%Amiodarone%C-reactive protein
目的 观察辛伐他汀联合胺碘酮对心房颤动转复后维持窦性心律的用法及临床效果.方法 回顾性分析2008年8月至2012年10月收治的74例阵发性心房颤动患者的临床资料,心房颤动转复后随机分为对照组及观察组各47例,对照组患者给予胺碘酮治疗,观察组同时给予辛伐他汀.比较两组患者治疗前后C-反应蛋白(CRP)水平,治疗后6个月及1年内房颤复发例数及不良反应发生情况.结果 用药6个月后观察组患者CRP水平明显低于对照组;治疗6个月、12个月后观察组患者窦性心律维持率分别为94.6％、89.2％,对照组分别为78.4％、70.3％,组间比较差异均有统计学意义(P＜0.05).两组患者均无明显不良反应发生.结论 辛伐他汀联合胺碘酮对心房颤动患者转复后维持窦性心律效果明显优于单用胺碘酮,临床应用安全、有效.
目的 觀察辛伐他汀聯閤胺碘酮對心房顫動轉複後維持竇性心律的用法及臨床效果.方法 迴顧性分析2008年8月至2012年10月收治的74例陣髮性心房顫動患者的臨床資料,心房顫動轉複後隨機分為對照組及觀察組各47例,對照組患者給予胺碘酮治療,觀察組同時給予辛伐他汀.比較兩組患者治療前後C-反應蛋白(CRP)水平,治療後6箇月及1年內房顫複髮例數及不良反應髮生情況.結果 用藥6箇月後觀察組患者CRP水平明顯低于對照組;治療6箇月、12箇月後觀察組患者竇性心律維持率分彆為94.6％、89.2％,對照組分彆為78.4％、70.3％,組間比較差異均有統計學意義(P＜0.05).兩組患者均無明顯不良反應髮生.結論 辛伐他汀聯閤胺碘酮對心房顫動患者轉複後維持竇性心律效果明顯優于單用胺碘酮,臨床應用安全、有效.
목적 관찰신벌타정연합알전동대심방전동전복후유지두성심률적용법급림상효과.방법 회고성분석2008년8월지2012년10월수치적74례진발성심방전동환자적림상자료,심방전동전복후수궤분위대조조급관찰조각47례,대조조환자급여알전동치료,관찰조동시급여신벌타정.비교량조환자치료전후C-반응단백(CRP)수평,치료후6개월급1년내방전복발례수급불량반응발생정황.결과 용약6개월후관찰조환자CRP수평명현저우대조조;치료6개월、12개월후관찰조환자두성심률유지솔분별위94.6％、89.2％,대조조분별위78.4％、70.3％,조간비교차이균유통계학의의(P＜0.05).량조환자균무명현불량반응발생.결론 신벌타정연합알전동대심방전동환자전복후유지두성심률효과명현우우단용알전동,림상응용안전、유효.
Objective To observe the usage and clinical effect of simvastatin combined with amiodarone to maintain sinus rhythm after the atrial fibrillation cardioversion.Methods The clinical data of 74 patients with paroxysmal atrial fibrillation treated in the fifth people' s hospital of Yongcheng from August 2008 to October 2010 were retrospectively analyzed.After the atrial fibrillation cardioversion,the patients were randomly divided into control group and observation group,for each group with 47 cases.The patients in control group were treated with amiodarone,and the patients in observation group were treated with simvastatin and amiodarone.The CRP levels before therapy and after therapy,atrial fibrillation recurrence cases and adverse effects within 6 moths and 1 year were compared.Results The CRP level in the observation group was obviously lower than that in control group after 6 months of medication.Six months and 12 months later,the sinus rhythm in the observation group was respectively 94.6％,89.2％,that in the control group was respectively 78.4％,70.3％,there were significant differences among the groups (P ＜ 0.05).There were no adverse reactions.Conclusions The clinical effect of simvastatin combined with amiodarone on maintaining sinus rhythm after the atrial fibrillation cardioversion is obviously superior to amiodarone only,besides,the clinical application is secure and effective.
