中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
1期
31-32
,共2页
田李霞%马希涛%王思勤%张晓菊%孔令非
田李霞%馬希濤%王思勤%張曉菊%孔令非
전리하%마희도%왕사근%장효국%공령비
骨膜蛋白%间质性肺炎%免疫组织化学
骨膜蛋白%間質性肺炎%免疫組織化學
골막단백%간질성폐염%면역조직화학
Periostin%Interstitial pneumonia%Immunohistochemistry
目的 探讨骨膜蛋白在纤维化型特发性非特异性间质性肺炎(f-INSIP)患者肺组织中的表达.方法 选取2002年8月至2012年3月在河南省人民医院住院的11例经开胸肺活检病理证实为f-INSIP的肺标本,对照组为在河南省人民医院因肺内孤立癌结节行肺叶切除术的住院患者,取其远离病变的正常肺组织标本11例.采用免疫组织化学方法检测肺标本中骨膜蛋白的表达.结果 免疫组化检测显示:f-INSIP患者肺组织中骨膜蛋白在纤维化周边表达阳性率(8/11)明显高于对照组(1/11),差异有统计学意义(P＜0.05).结论 骨膜蛋白参与f-INSIP的发病进程.
目的 探討骨膜蛋白在纖維化型特髮性非特異性間質性肺炎(f-INSIP)患者肺組織中的錶達.方法 選取2002年8月至2012年3月在河南省人民醫院住院的11例經開胸肺活檢病理證實為f-INSIP的肺標本,對照組為在河南省人民醫院因肺內孤立癌結節行肺葉切除術的住院患者,取其遠離病變的正常肺組織標本11例.採用免疫組織化學方法檢測肺標本中骨膜蛋白的錶達.結果 免疫組化檢測顯示:f-INSIP患者肺組織中骨膜蛋白在纖維化週邊錶達暘性率(8/11)明顯高于對照組(1/11),差異有統計學意義(P＜0.05).結論 骨膜蛋白參與f-INSIP的髮病進程.
목적 탐토골막단백재섬유화형특발성비특이성간질성폐염(f-INSIP)환자폐조직중적표체.방법 선취2002년8월지2012년3월재하남성인민의원주원적11례경개흉폐활검병리증실위f-INSIP적폐표본,대조조위재하남성인민의원인폐내고립암결절행폐협절제술적주원환자,취기원리병변적정상폐조직표본11례.채용면역조직화학방법검측폐표본중골막단백적표체.결과 면역조화검측현시:f-INSIP환자폐조직중골막단백재섬유화주변표체양성솔(8/11)명현고우대조조(1/11),차이유통계학의의(P＜0.05).결론 골막단백삼여f-INSIP적발병진정.
Objective To investigate the expression of periostin in lung tissue of fibrotic idiopathic nonspecific interstitial pneumonia (f-INSIP).Methods Eleven patients with f-INSIP confirmed by surgical lung biopsy from August 2002 to March 2012 admitted in the Henan provincial people' s hospital were enrolled.Eleven normal lung samples were obtained from patients with lung cancer by surgical resections as the control group.Immunohistochemistry was used to detect the expression of periostin.Results Immunohistochemical result showed that the positive expression rate of periostin in patients with fINSIP was significantly higher than that in the control group (P ＜ 0.05).Conclusions Periostin may participate in the pathogenic process of f-INSIP.
