CAJ | 학술논문

目的探讨热化疗治疗非小细胞肺癌(NSCLC)对白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)及肿瘤坏死因子(TNF)的影响.方法回顾性分析大同大学附属医院2004年10月至2013年1月收治的134例NSCLC患者,进行热疗联合NP方案化疗(NVB+ DDP),并分别在治疗前、治疗3个周期后、治疗6个周期后、治疗结束后3个月对患者血清中IL-2、IL-6、IL-8、IL-10及TNF的变化进行监测.结果热化疗3个周期后,IL-2、TNF水平逐渐增高,明显高于治疗前;IL-6、IL-8和IL-10水平明显低于化疗前.热化疗6个周期后,血IL-6、IL-8、IL-10、IL-2和TNF都有所下降,其中IL-2、TNF浓度显著低于化疗3个周期后的水平.热化疗结束后3个月,血IL-6、IL-8、IL-10水平继续下降;而IL-2、TNF浓度逐渐增高,低于化疗3个周期后的水平,但高于治疗前水平.结论热化疗治疗NSCLC对IL-2、TNF水平有明显的增高作用,而对IL-6、IL-8、IL-10有降低作用.
목적 탐토열화료치료비소세포폐암(NSCLC)대백세포개소-2(IL-2)、백세포개소-6(IL-6)、백세포개소-8(IL-8)、백세포개소-10(IL-10)급종류배사인자(TNF)적영향.방법 회고성분석대동대학부속의원2004년10월지2013년1월수치적134례NSCLC환자,진행열료연합NP방안화료(NVB+ DDP),병분별재치료전、치료3개주기후、치료6개주기후、치료결속후3개월대환자혈청중IL-2、IL-6、IL-8、IL-10급TNF적변화진행감측.결과 열화료3개주기후,IL-2、TNF수평축점증고,명현고우치료전;IL-6、IL-8화IL-10수평명현저우화료전.열화료6개주기후,혈IL-6、IL-8、IL-10、IL-2화TNF도유소하강,기중IL-2、TNF농도현저저우화료3개주기후적수평.열화료결속후3개월,혈IL-6、IL-8、IL-10수평계속하강;이IL-2、TNF농도축점증고,저우화료3개주기후적수평,단고우치료전수평.결론 열화료치료NSCLC대IL-2、TNF수평유명현적증고작용,이대IL-6、IL-8、IL-10유강저작용.
Objective To investigate the effect of hot therapy on interleukin-2 (IL-2),interleukin-6 (IL-6),interlerukin-8 (IL-8),interleukin-10 (IL-10) and tumor necrosis factor (TNF) in nonsmall cell lung cancer(NSCLC).Methods One hundred and thirty-four patients with NSCLC,admitted to our hospital from October 2004 to January 2013,received hot therapy and vinorelbine plus cisplatin (NP) chemotherapy.The IL-6,IL-8,IL-10 and TNF level before therapy,after 3 cycles,after 6 cycles and 3 months after chemotherapy were observed.Results IL-2 and TNF levels increased gradually after 3 cycles of hot therapy,and were significant higher than those before therapy.Compared to before therapy,IL-6,IL-8 and IL-10 levels significantly decreased.IL-6,IL-8,IL-10,IL-2 and TNF levels all decreased at 6 months after hot therapy.IL-2 and TNF levels were significant lowered than those of 3 cycles after chemotherapy.IL-6,IL-8 and IL-10 continued to decrease 3 months after the end of hot therapy,but the levels of IL-2,TNF increased gradually and were lower than the levels of 3 cycles after chemotherapy and were higher than the levels before therapy.Conclusions Hot therapy for NSCLC can significantly increase IL-2,TNF levels and decrease IL-6,IL-8,IL-10 levels.