中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
1期
46-48
,共3页
基质细胞衍生因子-1%超敏C-反应蛋白%远程缺血后处理
基質細胞衍生因子-1%超敏C-反應蛋白%遠程缺血後處理
기질세포연생인자-1%초민C-반응단백%원정결혈후처리
Stromal cell-derived factor-1%High-sensitivity C-reactive protein%Remote ischemic postconditioning
目的 探讨基质细胞衍生因子-1(SDF-1)在远程缺血后处理中的作用.方法 选择60例行择期经皮冠状动脉介入治疗(PCI)的不稳定型心绞痛患者,30例为常规治疗组,30例为远程缺血后处理组,测定其PCI术前及术后24 h的血清超敏C-反应蛋白(hs-CRP)及SDF-1水平,并分析其相关性.结果 两组在PCI术后血清hsCRP水平均较术前升高,SDF-1水平均较术前降低(P均＜0.05).与对照组比较,PCI术后远程缺血后处理组血清hs-CRP水平降低,血清SDF-1水平升高(P均＜0.05).PCI术前(r=-0.348,P＜0.05)及术后24h(r=-0.382,P＜0.05)血清hs-CRP及SDF-1的水平呈负相关.结论 SDF-1可能通过抗炎作用参与远程缺血后处理的心肌保护.
目的 探討基質細胞衍生因子-1(SDF-1)在遠程缺血後處理中的作用.方法 選擇60例行擇期經皮冠狀動脈介入治療(PCI)的不穩定型心絞痛患者,30例為常規治療組,30例為遠程缺血後處理組,測定其PCI術前及術後24 h的血清超敏C-反應蛋白(hs-CRP)及SDF-1水平,併分析其相關性.結果 兩組在PCI術後血清hsCRP水平均較術前升高,SDF-1水平均較術前降低(P均＜0.05).與對照組比較,PCI術後遠程缺血後處理組血清hs-CRP水平降低,血清SDF-1水平升高(P均＜0.05).PCI術前(r=-0.348,P＜0.05)及術後24h(r=-0.382,P＜0.05)血清hs-CRP及SDF-1的水平呈負相關.結論 SDF-1可能通過抗炎作用參與遠程缺血後處理的心肌保護.
목적 탐토기질세포연생인자-1(SDF-1)재원정결혈후처리중적작용.방법 선택60례행택기경피관상동맥개입치료(PCI)적불은정형심교통환자,30례위상규치료조,30례위원정결혈후처리조,측정기PCI술전급술후24 h적혈청초민C-반응단백(hs-CRP)급SDF-1수평,병분석기상관성.결과 량조재PCI술후혈청hsCRP수평균교술전승고,SDF-1수평균교술전강저(P균＜0.05).여대조조비교,PCI술후원정결혈후처리조혈청hs-CRP수평강저,혈청SDF-1수평승고(P균＜0.05).PCI술전(r=-0.348,P＜0.05)급술후24h(r=-0.382,P＜0.05)혈청hs-CRP급SDF-1적수평정부상관.결론 SDF-1가능통과항염작용삼여원정결혈후처리적심기보호.
Objective To investingate the effect of stromal cell-derived factor-1 (SDF-1) on remote ischemic postconditioning.Methods Sixty unstable angina patients underwent elective PCI were selected,with 30 cases in conventional treatment group and 30 cases in remote ischemic postconditioning group.The serum high-sensitivity C-reactive protein(hs-CRP) and SDF-1 levels were detected before PCI operation and 24 h postoperatively,and their reletionship was analyzed.Results The serum hs-CRP levels rised and SDF-1 levels decreased after PCI in the two groups (P ＜ 0.05).Compared with control group,serum hs-CRP levels reduced and SDF-1 levels increased after PCI in remote ischemic postconditioning group(P ＜0.05).Serum hs-CRP levels were negatively correlated with SDF-1 levels before PCI (r=-0.348,P＜0.05)and at24 h afterPCI(r=-0.382,P＜0.05).Conclusions SDF-1 may involved in remote ischemic postconditioning myocardial preservation through anti-inflammatory effect.
