中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
2期
39-42
,共4页
新生儿窒息%自然杀伤细胞%T淋巴细胞亚群%早产%免疫功能
新生兒窒息%自然殺傷細胞%T淋巴細胞亞群%早產%免疫功能
신생인질식%자연살상세포%T림파세포아군%조산%면역공능
Neonatal asphyxia%NK cells%T-lymphocyte subsets%Premature delivery%Immunity
目的 探讨围生期窒息对早产儿自然杀伤(NK)细胞及T淋巴细胞亚群水平变化的影响及其临床意义.方法 采用流式细胞仪对31例轻度窒息早产儿及25例重度窒息早产儿生后2h静脉血T淋巴细胞亚群进行测定,对照组为同期在本科住院的无窒息早产儿30例.结果 重度窒息组CD3-/CD16+ CD56+,CD3+、CD4+、CD4 +/CD8+明显低于对照组与轻度窒息组,差异有统计学意义(P＜0.05);轻度窒息组CD3-/CD16+ CD56+,CD3+、CD4+、CD4 +/CD8+亦明显低于对照组,差异有统计学意义(P＜0.05);轻重度窒息组各项指标与对照组比较差异无统计学意义,但均高于对照组,P＞0.05.结论 窒息缺氧可导致早产儿NK细胞及T淋巴细胞亚群紊乱,随着窒息程度加重,早产儿免疫功能改变愈加显著.
目的 探討圍生期窒息對早產兒自然殺傷(NK)細胞及T淋巴細胞亞群水平變化的影響及其臨床意義.方法 採用流式細胞儀對31例輕度窒息早產兒及25例重度窒息早產兒生後2h靜脈血T淋巴細胞亞群進行測定,對照組為同期在本科住院的無窒息早產兒30例.結果 重度窒息組CD3-/CD16+ CD56+,CD3+、CD4+、CD4 +/CD8+明顯低于對照組與輕度窒息組,差異有統計學意義(P＜0.05);輕度窒息組CD3-/CD16+ CD56+,CD3+、CD4+、CD4 +/CD8+亦明顯低于對照組,差異有統計學意義(P＜0.05);輕重度窒息組各項指標與對照組比較差異無統計學意義,但均高于對照組,P＞0.05.結論 窒息缺氧可導緻早產兒NK細胞及T淋巴細胞亞群紊亂,隨著窒息程度加重,早產兒免疫功能改變愈加顯著.
목적 탐토위생기질식대조산인자연살상(NK)세포급T림파세포아군수평변화적영향급기림상의의.방법 채용류식세포의대31례경도질식조산인급25례중도질식조산인생후2h정맥혈T림파세포아군진행측정,대조조위동기재본과주원적무질식조산인30례.결과 중도질식조CD3-/CD16+ CD56+,CD3+、CD4+、CD4 +/CD8+명현저우대조조여경도질식조,차이유통계학의의(P＜0.05);경도질식조CD3-/CD16+ CD56+,CD3+、CD4+、CD4 +/CD8+역명현저우대조조,차이유통계학의의(P＜0.05);경중도질식조각항지표여대조조비교차이무통계학의의,단균고우대조조,P＞0.05.결론 질식결양가도치조산인NK세포급T림파세포아군문란,수착질식정도가중,조산인면역공능개변유가현저.
Objective To investigate the effect of asphyxia in perinatal period on NK cell and T-lymphocyte subsets levels in preterm infants.Methods Flow cytometers was used to detect the venous blood T-lymphocyte subsets levels of 31 preterm infants with mild asphyxia and 25 premature infants with severe asphyxia at 2 hours after birth.At the same period,30 preterm infants without asphyxia hospitalized in our department were enrolled as control group.Results Compared with the control group and the mild asphyxia group,CD3-/CD16+ CD56+,CD3+,CD4+,CD4/+ CD8+ of the severe asphyxia group significantly decreased(P ＜ 0.05) ; CD3-/CD16+ CD56+ and CD3+,CD4+,CD4+/CD8+ of the mild asphyxia group were lower than those in the control group,there were significant differences (P ＜ 0.05).There was no significant difference in each indexes between mild and severe asphyxia group and control group,but both of them were higher than that in the control group (P ＞ 0.05).Conclusions Asphyxia can cause disturbance of T-lymphocyte subsets in preterm infants and the more severe of asphyxia,the more dramatic change of NK cell and T-lymphocyte subsets have been found.
