CAJ | 학술논문

目的探讨多囊卵巢综合征(PCOS)患者血管内皮功能损伤的情况,以及其与代谢性指标相关性的研究.方法 30例PCOS患者和20例的正常妇女(对照组)为研究对象;于月经期第3天抽取空腹静脉血去血清,检测血清选择素E (E-selectin)、内皮素-1(ET-1)和血管内皮vWF因子水平及总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)的水平变化;测定空腹胰岛素及血糖(FBG)水平.结果 PCOS组血浆E-selectin和vWF、TG和LDL-C、血浆空腹血糖和胰岛素水平明显高于正常对照组(P均＜0.05).PCOS患者血浆E-selectin与血糖、胰岛素及血三酰甘油呈正相关,r值分别为0.44、0.56和0.61,P均＜0.05;尚不能认为与血胆固醇相关.PCOS患者血浆vWF与血糖、胰岛素及血三酰甘油呈正相关,r值分别为0.48,0.52和0.63,P均＜0.05;尚不能认为与血胆固醇相关.PCOS组患者血ET-1仅与总胆固醇呈正相关性,r值为0.49,P＜0.05.结论 PCOS患者中E-selectin和vWF的升高提示了其血管内皮功能受损,血糖、高胰岛素和血脂升高是PCOS中影响血管内皮损伤的重要因子.
목적 탐토다낭란소종합정(PCOS)환자혈관내피공능손상적정황,이급기여대사성지표상관성적연구.방법 30례PCOS환자화20례적정상부녀(대조조)위연구대상;우월경기제3천추취공복정맥혈거혈청,검측혈청선택소E (E-selectin)、내피소-1(ET-1)화혈관내피vWF인자수평급총담고순(TC)、삼선감유(TG)、저밀도지단백담고순(LDL-C)화고밀도지단백담고순(HDL-C)적수평변화;측정공복이도소급혈당(FBG)수평.결과 PCOS조혈장E-selectin화vWF、TG화LDL-C、혈장공복혈당화이도소수평명현고우정상대조조(P균＜0.05).PCOS환자혈장E-selectin여혈당、이도소급혈삼선감유정정상관,r치분별위0.44、0.56화0.61,P균＜0.05;상불능인위여혈담고순상관.PCOS환자혈장vWF여혈당、이도소급혈삼선감유정정상관,r치분별위0.48,0.52화0.63,P균＜0.05;상불능인위여혈담고순상관.PCOS조환자혈ET-1부여총담고순정정상관성,r치위0.49,P＜0.05.결론 PCOS환자중E-selectin화vWF적승고제시료기혈관내피공능수손,혈당、고이도소화혈지승고시PCOS중영향혈관내피손상적중요인자.
Objective To investigate the endothelial dysfunction in patients with polycystic ovary syndrome(PCOS) and its correlation with metabolic status.Methods Thirty patients with PCOS and 20 normal women(NGT group) were enrolled in the study.Fasting blood samples were drawn from the vein on the third day of the menstrual cycle.Plasma levels of ET-1,vWF and soluble E-selectin were detected by ELISA.Lipid metabolism (total cholesterol,HDL-cholesterol,LDL-cholesterol,triglycerides) and glucose were also detected.Results The study showed higher levels of vWF,E-selectin,insulin and glucose and TG,LDL in PCOS patients versus healthy women(all P ＜0.05).A positive correlation was demonstrated between E-selectin and glucose,triglycerides and insulin (all P ＜ 0.05).vWF levels showed a positive correlation with glucose and triglycerides (all P ＜ 0.05).A positive correlation was also found between ET-1 and total cholesterol levels in PCOS women(P ＜0.05).Conclusions Elevated levels of vWF:Ag and E-selectin in PCOS women suggest endothelial dysfunction in this group of patients.Glucose and hyperinsulinism,hyperlipemia are significant factors affecting endothelial function in PCOS.