中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
2期
61-63
,共3页
肝硬化%谷氨酰胺%二胺氧化酶%内毒素血症%肠黏膜屏障
肝硬化%穀氨酰胺%二胺氧化酶%內毒素血癥%腸黏膜屏障
간경화%곡안선알%이알양화매%내독소혈증%장점막병장
Cirrhosis%Glutamine%Diamine oxidase%Endotoxemia%Intestinal mucosa barrier
目的 评价肝硬化患者肠黏膜屏障功能及静脉补充谷氨酰胺双肽对其的影响.方法 43例肝硬化患者随机分为两组,均给予等氮等热量营养支持10 d;研究组22例,给予谷氨酰胺双肽0.3 g/(kg·d),剩余氮量由平衡氨基酸提供;对照组21例,仅由平衡氨基酸提供氮源.采用分光光度法定量检测两组患者治疗前后外周血中二胺氧化酶(DAO)和内毒素(ETX)水平.另以15例健康志愿者作为正常组.结果 肝硬化患者组DAO及ETX水平显著高于正常组(P＜0.01);研究组治疗后血DAO及ETX水平较治疗前显著降低(P＜0.05),且显著低于对照组治疗后水平(P＜0.05);肝硬化患者血DAO与ETX水平呈正相关(r=0.269,P＜0.05);两组治疗过程中均未见明显不良反应发生.结论 对肝硬化患者补充谷氨酰胺双肽可能有助于改善肠黏膜屏障功能,从而减少内毒素血症的发生,使用过程相对安全.
目的 評價肝硬化患者腸黏膜屏障功能及靜脈補充穀氨酰胺雙肽對其的影響.方法 43例肝硬化患者隨機分為兩組,均給予等氮等熱量營養支持10 d;研究組22例,給予穀氨酰胺雙肽0.3 g/(kg·d),剩餘氮量由平衡氨基痠提供;對照組21例,僅由平衡氨基痠提供氮源.採用分光光度法定量檢測兩組患者治療前後外週血中二胺氧化酶(DAO)和內毒素(ETX)水平.另以15例健康誌願者作為正常組.結果 肝硬化患者組DAO及ETX水平顯著高于正常組(P＜0.01);研究組治療後血DAO及ETX水平較治療前顯著降低(P＜0.05),且顯著低于對照組治療後水平(P＜0.05);肝硬化患者血DAO與ETX水平呈正相關(r=0.269,P＜0.05);兩組治療過程中均未見明顯不良反應髮生.結論 對肝硬化患者補充穀氨酰胺雙肽可能有助于改善腸黏膜屏障功能,從而減少內毒素血癥的髮生,使用過程相對安全.
목적 평개간경화환자장점막병장공능급정맥보충곡안선알쌍태대기적영향.방법 43례간경화환자수궤분위량조,균급여등담등열량영양지지10 d;연구조22례,급여곡안선알쌍태0.3 g/(kg·d),잉여담량유평형안기산제공;대조조21례,부유평형안기산제공담원.채용분광광도법정량검측량조환자치료전후외주혈중이알양화매(DAO)화내독소(ETX)수평.령이15례건강지원자작위정상조.결과 간경화환자조DAO급ETX수평현저고우정상조(P＜0.01);연구조치료후혈DAO급ETX수평교치료전현저강저(P＜0.05),차현저저우대조조치료후수평(P＜0.05);간경화환자혈DAO여ETX수평정정상관(r=0.269,P＜0.05);량조치료과정중균미견명현불량반응발생.결론 대간경화환자보충곡안선알쌍태가능유조우개선장점막병장공능,종이감소내독소혈증적발생,사용과정상대안전.
Objective To evaluate the function of intestinal mucosa barrier in cirrhosis patients and the effects of alanyl-glutamine dipeptide supply on intestinal mucosa barrier in cirrhosis patients.Methods Forty-three patients were randomly divided into two groups:study group(22 cases) and control group(21 cases).All of the patients received isocaloric and isonitrogenic parenteral nutritional support daily for 10 days.The patients in study group were given glutamine at the dose of 0.3 g/(kg · d),while the patients in control group were given conventional common amino acid at the same dose.The normal group included 15 healthy people.The serum levels of DAO and ETX in 43 cirrhosis patients were detected before and after treatment by spectrophotometry in each group.Results The levels of DAO and ETX in cirrhosis group were significantly higher than those in normal group(P ＜ 0.01).After treatment,the serum levels of DAO and ETX in study group decreased (P ＜ 0.05).Moreover,these were significantly lower than those in control group (P ＜ 0.05).The serum level of DAO was correlated with the level of ETX in cirrhosis patients (r =0.269,P ＜ 0.05).There was no adverse reaction during treatment.Conclusions Alanyl-glutamine dipeptide is safe and beneficial for cirrhosis patients,which may be helpful to improve the function of intestinal mucosa barrier and reduce the incidence of endotoxemia.
