中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
3期
4-6
,共3页
曾宇然%王伟鸿%卢敏%严丽君
曾宇然%王偉鴻%盧敏%嚴麗君
증우연%왕위홍%로민%엄려군
血小板源性生长因子BB%血液透析%动脉粥样硬化
血小闆源性生長因子BB%血液透析%動脈粥樣硬化
혈소판원성생장인자BB%혈액투석%동맥죽양경화
Platelet derived growth factor-BB%Hemodialysis%Atherosclerosis
目的 测定血液透析患者血小板源性生长因子BB(PDGF-BB)水平,探讨其在血液透析患者颈动脉粥样硬化发生发展中的意义.方法 选择维持性血液透析患者68例,应用彩色多普勒超声显像仪检查两组样本的颈动脉内膜-中层厚度(IMT)及所探测到的斑块情况,将其分为合并颈动脉粥样硬化组和无合并颈动脉粥样硬化组,然后采用酶联免疫吸附法测定两组样本的血浆PDGF-BB水平及血小板第4因子(PF4)水平,对两组研究指标进行统计学分析.结果 维持性血液透析患者颈动脉粥样硬化阳性率为69.1％,合并颈动脉粥样硬化组血浆PDGF-BB水平均较无合并颈动脉粥样硬化组高[(104±28) pg/ml vs (76±15) pg/ml,P＜0.01],PF4水平同样是增高的[(578±125)ng/L vs (457±60) ng/L,P＜0.05];多元线性逐步回归分析显示血液透析患者血浆PDGF-BB水平、患者年龄均为影响颈动脉IMT的重要因素.结论 血液透析患者血浆PDGF-BB水平增高对其颈动脉粥样硬化发生有重要作用.
目的 測定血液透析患者血小闆源性生長因子BB(PDGF-BB)水平,探討其在血液透析患者頸動脈粥樣硬化髮生髮展中的意義.方法 選擇維持性血液透析患者68例,應用綵色多普勒超聲顯像儀檢查兩組樣本的頸動脈內膜-中層厚度(IMT)及所探測到的斑塊情況,將其分為閤併頸動脈粥樣硬化組和無閤併頸動脈粥樣硬化組,然後採用酶聯免疫吸附法測定兩組樣本的血漿PDGF-BB水平及血小闆第4因子(PF4)水平,對兩組研究指標進行統計學分析.結果 維持性血液透析患者頸動脈粥樣硬化暘性率為69.1％,閤併頸動脈粥樣硬化組血漿PDGF-BB水平均較無閤併頸動脈粥樣硬化組高[(104±28) pg/ml vs (76±15) pg/ml,P＜0.01],PF4水平同樣是增高的[(578±125)ng/L vs (457±60) ng/L,P＜0.05];多元線性逐步迴歸分析顯示血液透析患者血漿PDGF-BB水平、患者年齡均為影響頸動脈IMT的重要因素.結論 血液透析患者血漿PDGF-BB水平增高對其頸動脈粥樣硬化髮生有重要作用.
목적 측정혈액투석환자혈소판원성생장인자BB(PDGF-BB)수평,탐토기재혈액투석환자경동맥죽양경화발생발전중적의의.방법 선택유지성혈액투석환자68례,응용채색다보륵초성현상의검사량조양본적경동맥내막-중층후도(IMT)급소탐측도적반괴정황,장기분위합병경동맥죽양경화조화무합병경동맥죽양경화조,연후채용매련면역흡부법측정량조양본적혈장PDGF-BB수평급혈소판제4인자(PF4)수평,대량조연구지표진행통계학분석.결과 유지성혈액투석환자경동맥죽양경화양성솔위69.1％,합병경동맥죽양경화조혈장PDGF-BB수평균교무합병경동맥죽양경화조고[(104±28) pg/ml vs (76±15) pg/ml,P＜0.01],PF4수평동양시증고적[(578±125)ng/L vs (457±60) ng/L,P＜0.05];다원선성축보회귀분석현시혈액투석환자혈장PDGF-BB수평、환자년령균위영향경동맥IMT적중요인소.결론 혈액투석환자혈장PDGF-BB수평증고대기경동맥죽양경화발생유중요작용.
Objective To measure the platelet derived growth factor-BB (PDGF-BB) levels in maintence hemodialysis patients and investigate its significance in carotid atherosclerosis.Methods Sixty-eight patients with hemodialysis were enrolled in this study.Intima-media thickness(IMT) and prevalence of atherosclerotic plaques of the extracranial common carotid artery were measured by echocardiography.The serum PDGF-BB and platelet factor4 (PF4) were measured by enzyme-linked immunosorbent assay in all patients.Results The level of serum PDGF-BB in atherosclerosis group of hemodialysis patients were significantly higher than that in the non-atherosclerotic plaques group [(104 ± 28)pg/ml vs (76 ± 15)pg/ml,P ＜0.01],the level of serum PF4 in atherosclerosis group of hemodialysis patients were significantly higher than that in non-atherosclerotic plaques group[(578 ± 125)ng/L vs (457 ± 60)ng/L,P ＜ 0.05].Multiple stepwise regression analysis indicated that the factor impacting IMT were level of PDGF-BB and age.Conclusions The level of serum PDGF-BB is raised in maintence hemodialysis patients,it maybe play an important role in the formation of carotid atherosclerosis.
