中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
3期
24-25
,共2页
鲍智颖%钟小兵%康平%朱海清
鮑智穎%鐘小兵%康平%硃海清
포지영%종소병%강평%주해청
帕金森病%脑梗死%同型半胱氨酸%叶酸
帕金森病%腦梗死%同型半胱氨痠%葉痠
파금삼병%뇌경사%동형반광안산%협산
Parkinson's disease%Cerebral infarction%Homocysteine%Folate
目的 探讨血浆同型半胱氨酸(Hcy)水平与帕金森病(PD)之间的相关性.方法 检测PD、脑梗死患者及对照组血浆Hcy水平,检测PD、脑梗死患者及对照组血浆叶酸和维生素B12水平.对PD患者血浆Hcy水平与叶酸及维生素B12水平进行相关性分析.结果 PD组、脑梗死组及对照组的Hcy浓度分别是(15.7±2.8)、(17.2±4.4)及(10.2±2.5)μmol/L,PD组和脑梗死组血浆Hcy明显高于对照组,差异有统计学意义(P＜0.05).另外,经相关回归分析示:被检者血中血浆Hcy水平与叶酸及维生素B12水平存在负相关.结论 PD组、脑梗死组及对照组之间的血中Hcy水平不尽相同.Hcy水平与PD、脑梗死的发生有一定联系,并与维生素B12、叶酸呈负相关.
目的 探討血漿同型半胱氨痠(Hcy)水平與帕金森病(PD)之間的相關性.方法 檢測PD、腦梗死患者及對照組血漿Hcy水平,檢測PD、腦梗死患者及對照組血漿葉痠和維生素B12水平.對PD患者血漿Hcy水平與葉痠及維生素B12水平進行相關性分析.結果 PD組、腦梗死組及對照組的Hcy濃度分彆是(15.7±2.8)、(17.2±4.4)及(10.2±2.5)μmol/L,PD組和腦梗死組血漿Hcy明顯高于對照組,差異有統計學意義(P＜0.05).另外,經相關迴歸分析示:被檢者血中血漿Hcy水平與葉痠及維生素B12水平存在負相關.結論 PD組、腦梗死組及對照組之間的血中Hcy水平不儘相同.Hcy水平與PD、腦梗死的髮生有一定聯繫,併與維生素B12、葉痠呈負相關.
목적 탐토혈장동형반광안산(Hcy)수평여파금삼병(PD)지간적상관성.방법 검측PD、뇌경사환자급대조조혈장Hcy수평,검측PD、뇌경사환자급대조조혈장협산화유생소B12수평.대PD환자혈장Hcy수평여협산급유생소B12수평진행상관성분석.결과 PD조、뇌경사조급대조조적Hcy농도분별시(15.7±2.8)、(17.2±4.4)급(10.2±2.5)μmol/L,PD조화뇌경사조혈장Hcy명현고우대조조,차이유통계학의의(P＜0.05).령외,경상관회귀분석시:피검자혈중혈장Hcy수평여협산급유생소B12수평존재부상관.결론 PD조、뇌경사조급대조조지간적혈중Hcy수평불진상동.Hcy수평여PD、뇌경사적발생유일정련계,병여유생소B12、협산정부상관.
Objective To investigate the relationship between serum homocysteine level and Parkinson' s disease (PD).Methods The levels of plasma Hcy,folic acid and vitamin B12 of patients with PD,cerebral infarction and control group were detected.The levels of plasma Hcy,folic acid and vitamin B12 of PD patients were analyzed.Results Hcy levels in patients with PD,cerebral infarction and control group were (15.7 ± 2.81),(17.18 ± 4.43) and (10.25 ± 2.53) μmol/L,respectively.Hcy level in patients with PD and cerebral infarction were all significantly higher than that of control group.Hcy level in PD patients was significantly higher than that in patients with cerebral infarction.Correlation analysis found that the plasma level of Hcy was negatively correlated with the plasma levels of folate and vitamin B12.Conclusions The levels of Hcy were different among PD,cerebral infarction and control group.Hcy might be correlated with PD and cerebral infarction.Moreover,the negative relationship existed between Hcy and folate,vitamin B12.
