中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
3期
44-46
,共3页
幽门螺杆菌%胃炎%组织病理学
幽門螺桿菌%胃炎%組織病理學
유문라간균%위염%조직병이학
Helicobacter pylori%Gastritis%Pathology
目的 对幽门螺杆菌(Hp)感染与胃黏膜疾病及其病理改变的相互关系进行分析和探讨.方法 选择700例胃黏膜疾病患者的胃黏膜活检切片作为研究对象,应用Giemsa染色和Warthin-Starry染色方法检测其中的Hp感染情况,并分析其与患者的胃黏膜疾病种类和标本病理变化之间的关系.结果 700例标本中Hp阳性463例,Hp检出率为66.14％,慢性浅表性胃炎、慢性萎缩性胃炎、胃溃疡和胃癌患者的胃黏膜活体标本中的Hp检出率分别为46.86％、69.46％、83.62％和98.65％,四种疾病的Hp检出率总体差异和两两之间差异均有统计学意义(P＜0.05);经过对所有标本的病理改变和Hp感染情况进行对比分析,结果显示发生萎缩性、活动性、伴肠化生、腺上皮不典型增生、淋巴滤泡形成等病理改变的标本中Hp的感染率显著升高(P＜0.05).结论 Hp感染与慢性胃炎、胃溃疡和胃癌等胃黏膜疾病及其病理变化具有相关关系,随着疾病的进展和组织病理结构变化的产生,Hp感染率呈现上升趋势,因此,及时对Hp进行根治对于防治胃黏膜疾病及其病理变化进展具有十分重要的意义.
目的 對幽門螺桿菌(Hp)感染與胃黏膜疾病及其病理改變的相互關繫進行分析和探討.方法 選擇700例胃黏膜疾病患者的胃黏膜活檢切片作為研究對象,應用Giemsa染色和Warthin-Starry染色方法檢測其中的Hp感染情況,併分析其與患者的胃黏膜疾病種類和標本病理變化之間的關繫.結果 700例標本中Hp暘性463例,Hp檢齣率為66.14％,慢性淺錶性胃炎、慢性萎縮性胃炎、胃潰瘍和胃癌患者的胃黏膜活體標本中的Hp檢齣率分彆為46.86％、69.46％、83.62％和98.65％,四種疾病的Hp檢齣率總體差異和兩兩之間差異均有統計學意義(P＜0.05);經過對所有標本的病理改變和Hp感染情況進行對比分析,結果顯示髮生萎縮性、活動性、伴腸化生、腺上皮不典型增生、淋巴濾泡形成等病理改變的標本中Hp的感染率顯著升高(P＜0.05).結論 Hp感染與慢性胃炎、胃潰瘍和胃癌等胃黏膜疾病及其病理變化具有相關關繫,隨著疾病的進展和組織病理結構變化的產生,Hp感染率呈現上升趨勢,因此,及時對Hp進行根治對于防治胃黏膜疾病及其病理變化進展具有十分重要的意義.
목적 대유문라간균(Hp)감염여위점막질병급기병리개변적상호관계진행분석화탐토.방법 선택700례위점막질병환자적위점막활검절편작위연구대상,응용Giemsa염색화Warthin-Starry염색방법검측기중적Hp감염정황,병분석기여환자적위점막질병충류화표본병리변화지간적관계.결과 700례표본중Hp양성463례,Hp검출솔위66.14％,만성천표성위염、만성위축성위염、위궤양화위암환자적위점막활체표본중적Hp검출솔분별위46.86％、69.46％、83.62％화98.65％,사충질병적Hp검출솔총체차이화량량지간차이균유통계학의의(P＜0.05);경과대소유표본적병리개변화Hp감염정황진행대비분석,결과현시발생위축성、활동성、반장화생、선상피불전형증생、림파려포형성등병리개변적표본중Hp적감염솔현저승고(P＜0.05).결론 Hp감염여만성위염、위궤양화위암등위점막질병급기병리변화구유상관관계,수착질병적진전화조직병리결구변화적산생,Hp감염솔정현상승추세,인차,급시대Hp진행근치대우방치위점막질병급기병리변화진전구유십분중요적의의.
Objective To analyze and investigate the relationship between Helicobacter pylori (Hp) infection and the gastric mucosa diseases and their pathological changes.Methods The gastric mucosa biopsy sections from 700 patients with gastric mucosa diseases were selected as the study objects.Hp infection of the biopsy sections was detected by Giemsa staining and Warthin-Starry staining method and the relationship between Hp infection and the gastric mucosa diseases and the pathological changes was analyzed.Results Among all 700 sections,there were 463 cases of Hp positive sections and the Hp positive detective rate was 66.14％.The Hp detection rates of the gastric mucosa biopsy sections from patients with chronic superficial gastritis,chronic atrophic gastritis,gastric ulcer and gastric cancer were 46.86％,69.46％,83.62％ and 98.65％.The overall difference of the Hp detection rates of the gastric mucosa biopsy sections from patients with each of the four diseases and the differences between every two diseases were significant (P ＜ 0.05) ; by analyzing the pathology changes and Hp infection of the gastric mucosa biopsy sections,the results showed the Hp infection rate of the gastric mucosa biopsy sections in which the pathological changes was atrophic changes,active changes,intestinal metaplasia,atypical hyperplasia of glandular epithelium,lymphoid follicles increased significantly (P ＜ 0.05).Conclusions Hp infection is correlated with the gastric mucosa diseases such as chronic gastritis,gastric ulcer and gastric cancer and their pathological changes.As the diseases progresses and the pathological structure changes,Hp infection rate showes a rising trend.Therefore,timely treatment of Hp infection is very important for prevention and treatment of gastric mucosal diseases and the progress of their pathological changes.
