中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
5期
9-11
,共3页
支气管哮喘%玉屏风颗粒%辅助性T细胞
支氣管哮喘%玉屏風顆粒%輔助性T細胞
지기관효천%옥병풍과립%보조성T세포
Bronchial asthma%Yupingfeng particles%Helper T lymphocyte
目的 探讨玉屏风颗粒对支气管哮喘的疗效及对患儿Th1/Th2免疫平衡的影响.方法 将132例非急性发作期轻、中度支气管哮喘患儿随机分为观察组及对照组,两组均予布地奈德气雾剂吸入,每次200 μg,每日2次.观察组另予口服玉屏风颗粒,6～9岁患儿每次5.0g,每天2次;10～14岁患儿每次5.0g,每天3次;每个疗程为1个月,每个疗程完成后停1周再进行另1个疗程,共进行5个疗程(6个月).6个月后观察两组治疗效果及外周血Th1、Th2及血清白细胞介素-4(IL-4)、γ-干扰素(IFN-γ)表达水平.结果 观察组和对照组患儿哮喘控制率分别为86.7％和68％,两组临床控制率比较差异有统计学意义(x2=5.57,P＜0.05).治疗前两组Th1、Th2及Th1/Th2比较差异无统计学意义;治疗后两组Th1均升高、Th2均下降,Th1/Th2均升高,但观察组改变(Th1升高、Th2下降,Th1/Th2升高)更明显,两组比较差异有统计学意义(P＜0.05);两组治疗后血清IL-4含量均下降,但观察组下降更明显,两组比较差异有统计学意义(P＜0.05);与治疗前比较,两组治疗后血清INF-γ含量均升高,但观察组升高更明显,两组比较差异有统计学意义(P＜0.05).结论 玉屏风颗粒能提高支气管哮喘的治疗效果,改善支气管哮喘患儿Th1/Th2免疫失衡及血清IL-4、IFN-γ的表达水平,值得临床广泛推广.
目的 探討玉屏風顆粒對支氣管哮喘的療效及對患兒Th1/Th2免疫平衡的影響.方法 將132例非急性髮作期輕、中度支氣管哮喘患兒隨機分為觀察組及對照組,兩組均予佈地奈德氣霧劑吸入,每次200 μg,每日2次.觀察組另予口服玉屏風顆粒,6～9歲患兒每次5.0g,每天2次;10～14歲患兒每次5.0g,每天3次;每箇療程為1箇月,每箇療程完成後停1週再進行另1箇療程,共進行5箇療程(6箇月).6箇月後觀察兩組治療效果及外週血Th1、Th2及血清白細胞介素-4(IL-4)、γ-榦擾素(IFN-γ)錶達水平.結果 觀察組和對照組患兒哮喘控製率分彆為86.7％和68％,兩組臨床控製率比較差異有統計學意義(x2=5.57,P＜0.05).治療前兩組Th1、Th2及Th1/Th2比較差異無統計學意義;治療後兩組Th1均升高、Th2均下降,Th1/Th2均升高,但觀察組改變(Th1升高、Th2下降,Th1/Th2升高)更明顯,兩組比較差異有統計學意義(P＜0.05);兩組治療後血清IL-4含量均下降,但觀察組下降更明顯,兩組比較差異有統計學意義(P＜0.05);與治療前比較,兩組治療後血清INF-γ含量均升高,但觀察組升高更明顯,兩組比較差異有統計學意義(P＜0.05).結論 玉屏風顆粒能提高支氣管哮喘的治療效果,改善支氣管哮喘患兒Th1/Th2免疫失衡及血清IL-4、IFN-γ的錶達水平,值得臨床廣汎推廣.
목적 탐토옥병풍과립대지기관효천적료효급대환인Th1/Th2면역평형적영향.방법 장132례비급성발작기경、중도지기관효천환인수궤분위관찰조급대조조,량조균여포지내덕기무제흡입,매차200 μg,매일2차.관찰조령여구복옥병풍과립,6～9세환인매차5.0g,매천2차;10～14세환인매차5.0g,매천3차;매개료정위1개월,매개료정완성후정1주재진행령1개료정,공진행5개료정(6개월).6개월후관찰량조치료효과급외주혈Th1、Th2급혈청백세포개소-4(IL-4)、γ-간우소(IFN-γ)표체수평.결과 관찰조화대조조환인효천공제솔분별위86.7％화68％,량조림상공제솔비교차이유통계학의의(x2=5.57,P＜0.05).치료전량조Th1、Th2급Th1/Th2비교차이무통계학의의;치료후량조Th1균승고、Th2균하강,Th1/Th2균승고,단관찰조개변(Th1승고、Th2하강,Th1/Th2승고)경명현,량조비교차이유통계학의의(P＜0.05);량조치료후혈청IL-4함량균하강,단관찰조하강경명현,량조비교차이유통계학의의(P＜0.05);여치료전비교,량조치료후혈청INF-γ함량균승고,단관찰조승고경명현,량조비교차이유통계학의의(P＜0.05).결론 옥병풍과립능제고지기관효천적치료효과,개선지기관효천환인Th1/Th2면역실형급혈청IL-4、IFN-γ적표체수평,치득림상엄범추엄.
Objective To investigate the clinical efficacy of Yupingfeng particles on bronchial asthma and immunologic balance of helper T lymphocyte 1/ helper T lymphocyte 2 (Th1/Th2).Methods One hundred and thirty-two children with non-acute stage mild to moderate bronchial asthma were randomly divided into observation group and control group,the patients in the two groups were all treated with Budesonide aerosol,200 μg per time,2 times a day;the patients in the observation group were additionally treated with Yupingfeng particles,for age from 6 to 9,5.0 g per time,2 times a day; for age from 10 to 14,5.0 g per time,3 times a day,the course of therapy was one month,after one course,there was 1 week of suspension,and then proceed to the next course,until the fifth course was completed.After 6 months,the clinical efficacy of the two groups was observed,the expression levels of Th1,Th2 were measured,and the levels of serum interleukin 4 (IL-4),interferon γ(IFN-γ) were detected.Results The clinical total effective rate in the observation group(86.7％) was higher than that in the control group(68％),there was significant difference between the two groups(x2 =5.57,P ＜0.05); the levels of Th1 in the two groups all increased,the levels of Th2 in the two groups all decreased,Th1/Th2 all increased,but the observation group (Th1 increased,Th2 decreased,Th1/Th2 increased) changed more significantly,there were significant differences between the two groups (P ＜ 0.05) ; the levels of IL-4 in serum decreased after the treatment in the two groups,but the observation group decreased more obviously,there were significant differences between the two groups (P ＜ 0.05) ; compared with before treatment in the two groups,the levels of INF-γ increased,but the observation group increased more obviously,there were significant differences between the two groups.Conclusions Yupingfeng particles is effective on bronchial asthma by adjusting immune imbalance of Th1/Th2 and the expression levels of serum IL-4,IFN-γ,is worthy of clinical application.
