中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
5期
54-56
,共3页
杨靖%张勇%王秀丽%邵玉单
楊靖%張勇%王秀麗%邵玉單
양정%장용%왕수려%소옥단
首发精神分裂症%氨磺必利%舒必利%疗效%生活质量
首髮精神分裂癥%氨磺必利%舒必利%療效%生活質量
수발정신분렬증%안광필리%서필리%료효%생활질량
First-episode schizophrenia%Amisulpride%Sulpiride%Efficacy%Quality of life
目的 探讨氨磺必利与舒必利治疗精神分裂症的疗效及对其生活质量的影响.方法 将94例首发精神分裂症患者随机分为氨磺必利组和舒必利组,观察8周.分别于治疗前及治疗2、4、8周末采用阳性和阴性症状量表(PANSS)评定疗效,用治疗时出现的症状量表(TESS)评定不良反应,用生活质量综合评定问卷(GQOLI-74)于治疗前和治疗8周末评定生活质量.结果 两组PANSS分值治疗前后差异均有统计学意义(P＜0.01),但两组间比较差异无统计学意义(P＞0.05);两组GQOLI-74评定除物质生活维度无明显变化,总分及躯体健康维度、心理健康维度、社会功能维度均显著升高(P ＜0.05或＜0.01),氨磺必利组优于舒必利组,差异有统计学意义(P＜0.05或＜0.01).结论 氨磺必利与舒必利治疗首发精神分裂症疗效相当,但氨磺必利组安全性高,依从性好,对患者的生活质量改善明显.
目的 探討氨磺必利與舒必利治療精神分裂癥的療效及對其生活質量的影響.方法 將94例首髮精神分裂癥患者隨機分為氨磺必利組和舒必利組,觀察8週.分彆于治療前及治療2、4、8週末採用暘性和陰性癥狀量錶(PANSS)評定療效,用治療時齣現的癥狀量錶(TESS)評定不良反應,用生活質量綜閤評定問捲(GQOLI-74)于治療前和治療8週末評定生活質量.結果 兩組PANSS分值治療前後差異均有統計學意義(P＜0.01),但兩組間比較差異無統計學意義(P＞0.05);兩組GQOLI-74評定除物質生活維度無明顯變化,總分及軀體健康維度、心理健康維度、社會功能維度均顯著升高(P ＜0.05或＜0.01),氨磺必利組優于舒必利組,差異有統計學意義(P＜0.05或＜0.01).結論 氨磺必利與舒必利治療首髮精神分裂癥療效相噹,但氨磺必利組安全性高,依從性好,對患者的生活質量改善明顯.
목적 탐토안광필리여서필리치료정신분렬증적료효급대기생활질량적영향.방법 장94례수발정신분렬증환자수궤분위안광필리조화서필리조,관찰8주.분별우치료전급치료2、4、8주말채용양성화음성증상량표(PANSS)평정료효,용치료시출현적증상량표(TESS)평정불량반응,용생활질량종합평정문권(GQOLI-74)우치료전화치료8주말평정생활질량.결과 량조PANSS분치치료전후차이균유통계학의의(P＜0.01),단량조간비교차이무통계학의의(P＞0.05);량조GQOLI-74평정제물질생활유도무명현변화,총분급구체건강유도、심리건강유도、사회공능유도균현저승고(P ＜0.05혹＜0.01),안광필리조우우서필리조,차이유통계학의의(P＜0.05혹＜0.01).결론 안광필리여서필리치료수발정신분렬증료효상당,단안광필리조안전성고,의종성호,대환자적생활질량개선명현.
Objective To investigate the efficacy and of amisulpride and sulpiride on treatment of patients with first-episode schizophrenia and its effect on patients' quality of life.Methods Ninetyfour patients with first-episode schizophrenia were randomly divided into sulpride group and amisulpride group.The treatment course was 8 weeks.Treatment efficacy and tolerability was evaluated using positive and negative syndrome scale(PANSS) and the treatment emergent symptom scale (TESS) at baseline and 2,4,8 weeks after treatment,respectively.Quality of life was evaluated using generic quality of life inventory-74(GQOLI-74) before treatment and 8 weeks after treatment.Results There were signiticant differences in the scores of PANSS before and after treatment in both groups(P ＜0.01).But there was no significant difference in PANSS scores between the two groups after treatment(P ＞ 0.05).There were significant differences in total score of GQOLI-74 and quality of physical health,psychological life and social function between the two groups (P ＜ 0.05 or ＜ 0.01),and amisulpride group was superior to sulpride group (P ＜ 0.05 or ＜ 0.01).Conclusions Amisulpride is as effective as sulpiride and is superior to sulpride in increasing quality of life in treatment of first-episode schizophrenia,and it has high safety and good compliance.
