CAJ | 학술논문

目的检测糖尿病肾病患者血清可溶性补体受体sCR1、胱抑素C(CysC)、β2微球蛋白(β2MG)和尿微量白蛋白(mAlb)的水平,研究其水平变化在早期诊断中的临床意义,为糖尿病肾病的临床诊断和治疗提供依据.方法选择82例糖尿病肾病患者作为糖尿病肾病组,65例健康体检者作为正常对照组.采用ELISA法检测样本血清中sCR1的含量水平,采用免疫比浊法检测血清中CysC、β2MG及尿mAlb的水平.用统计学方法分析患者血清中sCR1、CysC、β2MG及尿mAlb水平和疾病的相关性.结果糖尿病肾病患者血清中sCR1水平低于正常对照组(P＜0.01);CysC和β2MG在糖尿病肾病患者血清中含量高于正常对照组(P＜0.01);糖尿病肾病患者晨尿中mAlb水平显著高于健康对照组(P＜0.01).结论血清中sCR1在糖尿病肾病患者血清中显著降低,而CysC、β2 MG及尿mAlb含量则显著升高,与糖尿病肾病的病情进展有重要相关性.因此,sCR1、CysC、β2MG和mAlb可作为检测病情活动的辅助监测指标.提示sCR1、CysC、β2MG和mAlb可能在糖尿病肾病患者发病中起重要作用.
목적 검측당뇨병신병환자혈청가용성보체수체sCR1、광억소C(CysC)、β2미구단백(β2MG)화뇨미량백단백(mAlb)적수평,연구기수평변화재조기진단중적림상의의,위당뇨병신병적림상진단화치료제공의거.방법 선택82례당뇨병신병환자작위당뇨병신병조,65례건강체검자작위정상대조조.채용ELISA법검측양본혈청중sCR1적함량수평,채용면역비탁법검측혈청중CysC、β2MG급뇨mAlb적수평.용통계학방법분석환자혈청중sCR1、CysC、β2MG급뇨mAlb수평화질병적상관성.결과 당뇨병신병환자혈청중sCR1수평저우정상대조조(P＜0.01);CysC화β2MG재당뇨병신병환자혈청중함량고우정상대조조(P＜0.01);당뇨병신병환자신뇨중mAlb수평현저고우건강대조조(P＜0.01).결론 혈청중sCR1재당뇨병신병환자혈청중현저강저,이CysC、β2 MG급뇨mAlb함량칙현저승고,여당뇨병신병적병정진전유중요상관성.인차,sCR1、CysC、β2MG화mAlb가작위검측병정활동적보조감측지표.제시sCR1、CysC、β2MG화mAlb가능재당뇨병신병환자발병중기중요작용.
Objective To detect the levels of serum soluble complement receptor 1 (sCR1),cystatin C(CysC),β2 microglobulin(β2MG) and urine albumin(mAlb) in patients with diabetic nephropathy(DN),and study the effects of these factors on the diagnosis and treatment of diabetic nephropathy,in order to provide references for the early stage diagnosis and treatment of diabetic nephroathy.Methods Eighty-two DN patients were selected were chose as the experiment group and 65 healthy people as the control group.The serum level of sCR1 was detected by ELISA.The serum levels of CysC,β2MG and mAlb were measured by immunoturbidimetry.Then,the correlation of serum levels of sCR1,CysC,β2MG and mAlb with DN was analyzed.Results The serum level of sCR1 of DN patients was lower than that of healthy people.The levels of CysC,β2MG in serum and mAlb were higher in DN patients than that in healthy people (P ＜ 0.01).Conclusions The serum levels of sCR1,CysC,β2MG and mAlb are supplementary indicators for the progression of DN,suggesting that these factors may play an important role in the development of DN,so sCRI,cysc,β2 MG and mAlb can be used as supplementary monltoring indexes for the progression of DN.