CAJ | 학술논문

目的研究低度恶性黏液纤维肉瘤的临床特征、病理、分型、预后及治疗进展.方法对1例低度恶性黏液纤维肉瘤患者的临床资料、影像学表现、病理、治疗和预后进行报道,并结合国内外文献复习近年来有关低度恶性黏液纤维肉瘤的诊治进展.结果临床表现为四肢或躯干无痛缓慢生长的肿块,活检病理示:肿瘤细胞呈梭形浸润生长,呈结节状,可见黏液样背景及多核巨细胞、核分裂像,Vim(+)、SMA(+)、S-1 00(-)、Ki-67(10％～20％+)、CD34(血管+)、CD68(+).结论低度恶性黏液纤维肉瘤较少见,易复发,可发生转移,病理上易与其他黏液变的良恶性肿瘤相混淆,故正确的诊断和及时采取以手术切除为主的综合性治疗十分重要.
목적 연구저도악성점액섬유육류적림상특정、병리、분형、예후급치료진전.방법 대1례저도악성점액섬유육류환자적림상자료、영상학표현、병리、치료화예후진행보도,병결합국내외문헌복습근년래유관저도악성점액섬유육류적진치진전.결과 림상표현위사지혹구간무통완만생장적종괴,활검병리시:종류세포정사형침윤생장,정결절상,가견점액양배경급다핵거세포、핵분렬상,Vim(+)、SMA(+)、S-1 00(-)、Ki-67(10％～20％+)、CD34(혈관+)、CD68(+).결론 저도악성점액섬유육류교소견,역복발,가발생전이,병리상역여기타점액변적량악성종류상혼효,고정학적진단화급시채취이수술절제위주적종합성치료십분중요.
Objective To study the clinical characteristics,pathology,classification,prognosis and treatment of myxofibrosarcoma.Methods The clinical data,imaging findings,pathology,treatment and prognosis of the patient with low grade myxofibrosarcoma was analyzed.Results It frequently presents as a slowly enlarging painless mass often affects the extremities.An excisional biopsy showed spindle-shaped invasive growth of tumor cells in the loose myxoid stroma with multinucleated giant cells and mitotic.Immunohistochemical staining showed that the tumor cells were positive for the markers Vim (+),SMA(+),S-100(-),Ki-67(10％～20％ +),CD34(+),CD68(+).Conclusions MFS is a very rare soft tissue tumor that is often misdiagnosed as benign,and need to be differentiated from other tumor.Definite diagnosis of the malignancy depends on pathological examination.Low grade myxofibrosarcoma is malignancy with surgical resection mainly combined with postoperative radiotherapy and chemotherapy treatments if necessary.