中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2014年
23期
8-10
,共3页
2型糖尿病%阿卡波糖%肿瘤坏死因子-α%白细胞介素-6
2型糖尿病%阿卡波糖%腫瘤壞死因子-α%白細胞介素-6
2형당뇨병%아잡파당%종류배사인자-α%백세포개소-6
Type 2 diabetes mellitus%Acarbose%TNF-α%IL-6
目的 探讨阿卡波糖治疗2型糖尿病的疗效及对炎症因子的影响.方法 选取2012年1月至2013年12月收治的2型糖尿病患者共120例,按照随机数字表法分为观察组和对照组各60例.对照组给予饮食控制等非药物治疗,观察组在此基础上给予阿卡波糖治疗,疗程为12周.观察两组干预前后的空腹血糖、餐后2h血糖、糖化血红蛋白、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)炎症因子等指标.结果 干预前,两组的空腹血糖、餐后2h血糖与糖化血红蛋白比较差异无统计学意义(P＞0.05);干预后两组患者以上观察指标均明显降低,观察组低于对照组,差异有统计学意义(P＜0.05);干预前,两组的TNF-α、IL-6含量相当,差异无统计学意义(P＞0.05);干预后,两组患者以上两个指标均显著下降,观察组显著低于对照组,差异均有统计学意义(P＜0.05);两组均未出现严重不良反应.结论 阿卡波糖治疗2型糖尿病可以有效控制血糖,减轻胰岛素抵抗,是一种安全可靠的治疗方法.
目的 探討阿卡波糖治療2型糖尿病的療效及對炎癥因子的影響.方法 選取2012年1月至2013年12月收治的2型糖尿病患者共120例,按照隨機數字錶法分為觀察組和對照組各60例.對照組給予飲食控製等非藥物治療,觀察組在此基礎上給予阿卡波糖治療,療程為12週.觀察兩組榦預前後的空腹血糖、餐後2h血糖、糖化血紅蛋白、腫瘤壞死因子-α(TNF-α)、白細胞介素-6(IL-6)炎癥因子等指標.結果 榦預前,兩組的空腹血糖、餐後2h血糖與糖化血紅蛋白比較差異無統計學意義(P＞0.05);榦預後兩組患者以上觀察指標均明顯降低,觀察組低于對照組,差異有統計學意義(P＜0.05);榦預前,兩組的TNF-α、IL-6含量相噹,差異無統計學意義(P＞0.05);榦預後,兩組患者以上兩箇指標均顯著下降,觀察組顯著低于對照組,差異均有統計學意義(P＜0.05);兩組均未齣現嚴重不良反應.結論 阿卡波糖治療2型糖尿病可以有效控製血糖,減輕胰島素牴抗,是一種安全可靠的治療方法.
목적 탐토아잡파당치료2형당뇨병적료효급대염증인자적영향.방법 선취2012년1월지2013년12월수치적2형당뇨병환자공120례,안조수궤수자표법분위관찰조화대조조각60례.대조조급여음식공제등비약물치료,관찰조재차기출상급여아잡파당치료,료정위12주.관찰량조간예전후적공복혈당、찬후2h혈당、당화혈홍단백、종류배사인자-α(TNF-α)、백세포개소-6(IL-6)염증인자등지표.결과 간예전,량조적공복혈당、찬후2h혈당여당화혈홍단백비교차이무통계학의의(P＞0.05);간예후량조환자이상관찰지표균명현강저,관찰조저우대조조,차이유통계학의의(P＜0.05);간예전,량조적TNF-α、IL-6함량상당,차이무통계학의의(P＞0.05);간예후,량조환자이상량개지표균현저하강,관찰조현저저우대조조,차이균유통계학의의(P＜0.05);량조균미출현엄중불량반응.결론 아잡파당치료2형당뇨병가이유효공제혈당,감경이도소저항,시일충안전가고적치료방법.
Objective To study the the influence of acarbose on TNF-α and IL-6 in the treatment of type 2 diabetes mellitus.Methods One hundred and twenty patients with type 2 diabetes mellitus from January 2012 to December 2013 were selected and divided into observation group and control group randomly (60 cases in each group).The control group were given diet control and other non drug therapy,observation group were given acarbose therapy for 12 weeks treatment.The fasting blood glucose,2 h postprandial blood glucose,HbA1c,TNF-α and IL-6 of the two groups were observed before and after intervention.Results Before the intervention,there was no statistical significance in the indicators above (P ＞ 0.05).After intervention,all of the indexes were decreased,and the the change of observation group were more significant than that in the control group.The differences were significant (P ＜ 0.05).Before the intervention,TNF-α and IL-6 content were the equivalent between the two groups,and there was no statistical difference (P ＞ 0.05).After intervention,the two indexes were significantly decreased in both groups,and the observation group were significantly lower than that in the control group,and there were significant differences (all P ＜ 0.05).There were no serious adverse reactions in both groups.Conclusions Type 2 diabetes mellitus treated by acarbose can effectively control blood glucose,and reduce insulin resistance,and it therefore is a safe and reliable treatment method.
