CAJ | 학술논문

目的探讨贝那普利对心肌梗死大鼠心室重构及MMP-2表达的影响.方法选取240只雄性SD大鼠随机平均分为4组,即假手术组、卡托普利组、贝那普利组和心肌梗死,每组各60只,比较4组大鼠左室舒张末内径、左室收缩末内径、左室射血分数、左室舒张末期压力、全心重量/体质量、左室重量/体质量及血清MMP-2水平等.结果卡托普利组和贝那普利组左室舒张末内径、左室收缩末内径、左室射血分数、左室舒张末期压力、全心重量/体质量、左室重量/体质量及血清MMP-2水平较心肌梗死组均显著改善,组间比较差异有统计学意义(P＜0.05);但卡托普利组和贝那普利组左室舒张末内径、左室收缩末内径、左室射血分数、左室舒张末期压力、全心重量/体质量、左室重量/体质量及血清MMP-2水平组间比较差异无统计学意义(P＞0.05);卡托普利组和贝那普利组血清及心肌组织中MMP-2水平较心肌梗死组均显著改善,组间比较差异有统计学意义(P＜0.05).结论贝那普利可显著提高心肌梗死后左心室功能,减轻心室肥厚,延缓心室重构过程,相较于卡托普利改善作用无显著差别;而MMP-2参与到心肌梗死后心室重构发生发展过程中.
목적 탐토패나보리대심기경사대서심실중구급MMP-2표체적영향.방법 선취240지웅성SD대서수궤평균분위4조,즉가수술조、잡탁보리조、패나보리조화심기경사,매조각60지,비교4조대서좌실서장말내경、좌실수축말내경、좌실사혈분수、좌실서장말기압력、전심중량/체질량、좌실중량/체질량급혈청MMP-2수평등.결과 잡탁보리조화패나보리조좌실서장말내경、좌실수축말내경、좌실사혈분수、좌실서장말기압력、전심중량/체질량、좌실중량/체질량급혈청MMP-2수평교심기경사조균현저개선,조간비교차이유통계학의의(P＜0.05);단잡탁보리조화패나보리조좌실서장말내경、좌실수축말내경、좌실사혈분수、좌실서장말기압력、전심중량/체질량、좌실중량/체질량급혈청MMP-2수평조간비교차이무통계학의의(P＞0.05);잡탁보리조화패나보리조혈청급심기조직중MMP-2수평교심기경사조균현저개선,조간비교차이유통계학의의(P＜0.05).결론 패나보리가현저제고심기경사후좌심실공능,감경심실비후,연완심실중구과정,상교우잡탁보리개선작용무현저차별;이MMP-2삼여도심기경사후심실중구발생발전과정중.
Objective To investigate the influence of benazepril on ventricular remodeling and MMP-2 expression in rats with acute myocardial infarction.Methods The 240 male Wistar rats were selected and randomly divided into four groups including sham operation group (60 rats),captopril group (60 rats),benazepril group (60 rats) and myocardial infarctiong group (60 rats).The left ventricular end-diastolic diameter,left ventricular end-systolic diameter,left ventricular ejection fraction,the left ventricular end-diastolic pressure,heart weight / body weight,left ventricular weight / body weight,and serum MMP-2 levels of three groups were all compared.Results The left ventricular end-diastolic diameter,left ventricular end-systolic diameter,left ventricular ejection fraction,the left ventricular end-diastolic pressure,heart weight/body weight,left ventricular weight / body weight and serum MMP-2 levels of captopril group and benazepril group were significantly improved than sham operation group (P ＜ 0.05).But there was no significant differences in terms of left ventricular end-diastolic pressure,heart weight / body weight,left ventricular weight / body weight and serum MMP-2 levels between captopril group and benazepril group (P ＞ 0.05).Captopril group and benazepril group were significantly imp roved in serum and myocardial tissue MMP-2 levels compared with myocardial infarction group (P ＜ 0.05).Conclusions Benazepril treatment on rats with acute myocardial infarction can efficiently improve left ventricular function after myocardial infarction,reduce ventricular hypertrophy and delay the process of ventricular remodeling.There was no significant difference in improving degree between captopril and benazepril.MMP-2 contributed to the ventricular remodeling in acute myocardial infarction.