CAJ | 학술논문

目的探讨冠状动脉慢血流(CSF)患者血小板形态及功能的改变.方法经冠状动脉造影(CAG)诊断为CSF者38例,CAG显示无管腔狭窄且无慢血流者25例为对照组,使用校正的TIMI血流分级(CTFC)方法评价冠状动脉的血流速度.两组均采用ELISA法测定血小板α颗粒膜蛋白-140 (GMP-140)的浓度;进行血常规检验,测定血小板计数(PLT)、血小板平均体积(MPV)、血小板体积分布密度(PDW).比较两组GMP-140、PLT、MPV的水平,分析冠状动脉血流速度与GMP-140及MPV的相关性.结果 ①CSF组平均血流速度明显慢于对照组.②CSF组GMP-140及MPV水平明显高于对照组.③冠状动脉平均血流速度与GMP-140及MPV均呈正相关.结论血小板体积增大、聚集功能增强,提示冠状动脉慢血流患者处于较高的血小板活化状态,可以加速冠状动脉粥样硬化病变的发生发展.
목적 탐토관상동맥만혈류(CSF)환자혈소판형태급공능적개변.방법 경관상동맥조영(CAG)진단위CSF자38례,CAG현시무관강협착차무만혈류자25례위대조조,사용교정적TIMI혈류분급(CTFC)방법평개관상동맥적혈류속도.량조균채용ELISA법측정혈소판α과립막단백-140 (GMP-140)적농도;진행혈상규검험,측정혈소판계수(PLT)、혈소판평균체적(MPV)、혈소판체적분포밀도(PDW).비교량조GMP-140、PLT、MPV적수평,분석관상동맥혈류속도여GMP-140급MPV적상관성.결과 ①CSF조평균혈류속도명현만우대조조.②CSF조GMP-140급MPV수평명현고우대조조.③관상동맥평균혈류속도여GMP-140급MPV균정정상관.결론 혈소판체적증대、취집공능증강,제시관상동맥만혈류환자처우교고적혈소판활화상태,가이가속관상동맥죽양경화병변적발생발전.
Objective To compare the changes of the morphology and function of platelets in patients with coronary slow flow phenomenon(CSF).Methods Thirty-eight patients with CSF and 25 control cases with normal coronary flow (NCF) were enrolled in the study.Coronary flow speed of the cases were determined by thrombolysis in myocardial infarction (TIMI) frame count method.The platelet count (PLT),mean platelet volnme (MPV),and the platelet volume distribution width(PDW) were evaluated by blood routine examination.The CSF,NCF and GMP-140 were compared to with evaluate the relationship between coronary flow speed and MPV (mean platelet volume),coronary flow speed and GMP-140.Results Coronary flow speed of the patients with CSF was much slower than that of control group.The level of GMP-140 and MPV were much higher than that of control group.Coronary flow speed was positively associated with the GMP-140 and MPV.Conclusions The MPV increasing and the aggregation reinforcing indicate that the platelets of CSF patients in the state of activation,it may accelerate the progress of atherosclerosis.