食管鳞癌组织中Bmi-1的表达及临床意义
식관린암조직중Bmi-1적표체급림상의의
Expression of Bmi-1 in esophageal squamous cell carcinoma tissue and its clinical significance
  • 万方数据
    解放军医学院学报 해방군의학원학보
    Academic Journal of Chinese Pla Medical School
    2013年 1期 88-90 ,共3页

    孙永刚%谭绪云%杨小毛%杜选峰%王辉%马占元%袁利%曾青华%徐倩%赵倩%郑倩

    손영강%담서운%양소모%두선봉%왕휘%마점원%원리%증청화%서천%조천%정천

    食管鳞癌%Bmi-1%免疫组化%荧光定量PCR 食管鱗癌%Bmi-1%免疫組化%熒光定量PCR
    식관린암%Bmi-1%면역조화%형광정량PCR
    esophageal squamous cell carcinoma%Bmi-1%immunohistochemistry%fluorescent quantitative PCR
    目的探讨Bmi-1表达与食管鳞癌生物学行为之间的关系.方法应用免疫组化SP法和荧光定量PCR方法从蛋白和mRNA水平检测48例食管鳞癌组织中Bmi-1的表达.结果食管鳞癌组织中Bmi-1蛋白的表达量显著高于癌旁食管黏膜组织(P<0.01),mRNA水平表达与蛋白一致;Bmi-1蛋白高表达与组织分化程度及淋巴结转移有关(P<0.05),与年龄、性别、肿瘤大小无关(P>0.05).结论 Bmi-1在食管鳞癌中高表达,与疾病进展密切相关,可作为预测食管癌生物学行为、判断预后的一个参考指标.
    목적탐토Bmi-1표체여식관린암생물학행위지간적관계.방법응용면역조화SP법화형광정량PCR방법종단백화mRNA수평검측48례식관린암조직중Bmi-1적표체.결과식관린암조직중Bmi-1단백적표체량현저고우암방식관점막조직(P<0.01),mRNA수평표체여단백일치;Bmi-1단백고표체여조직분화정도급림파결전이유관(P<0.05),여년령、성별、종류대소무관(P>0.05).결론 Bmi-1재식관린암중고표체,여질병진전밀절상관,가작위예측식관암생물학행위、판단예후적일개삼고지표.
    Objective To study the relation between Bmi-1 expression in esophageal squamous cell carcinoma(ESCC) tissue and biological behavior of ESCC. Methods Expressions of Bmi-1 protein and mRNA in 48 ESCC tissue samples were detected by immunohistochemical SP and RT-PCR, respectively. Results The expression levels of Bmi-1 protein and mRNA were significantly higher in ESCC tissue samples than in its adjacent tissue samples(P<0.01). The over-expression of Bmi-1 protein was positively related with lymph node metastasis and differentiation of esophageal carcinoma(P<0.05), but not with age, sex, and tumor size. Conclusion Bmi-1 is over-expressed in ESCC, which is closely related with the progress of ESCC, and can be used as a predicting marker for its biological behavior and prognosis.
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