CAJ | 학술논문

目的了解我院耐亚胺培南鲍曼不动杆菌携带苯唑西林(oxacillin,OXA)基因型的情况,为医院感染监控及流行病学调查提供科学依据.方法采用多重PCR方法,分析2010年4-12月我院住院患者分离的耐亚胺培南鲍曼不动杆菌68株的OXA基因型.结果68株耐亚胺培南鲍曼不动杆菌中,7株只携带OXA-51基因(检出率约为10.29%),60株同时携带OXA-51和OXA-23基因(检出率约为88.24%),1株同时携带OXA-51和OXA-58基因(检出率约为1.47%),未扩增到OXA-24基因.结论我院耐亚胺培南鲍曼不动杆菌携带OXA基因以OXA-51+OXA-23基因型为主,实验室应加强对产酶菌株的监测.
목적료해아원내아알배남포만불동간균휴대분서서림(oxacillin,OXA)기인형적정황,위의원감염감공급류행병학조사제공과학의거.방법채용다중PCR방법,분석2010년4-12월아원주원환자분리적내아알배남포만불동간균68주적OXA기인형.결과68주내아알배남포만불동간균중,7주지휴대OXA-51기인(검출솔약위10.29%),60주동시휴대OXA-51화OXA-23기인(검출솔약위88.24%),1주동시휴대OXA-51화OXA-58기인(검출솔약위1.47%),미확증도OXA-24기인.결론아원내아알배남포만불동간균휴대OXA기인이OXA-51+OXA-23기인형위주,실험실응가강대산매균주적감측.
Objective To provide the scientific evidence for the control of hospital infection with imipenem-resistant Acinetobacter baumannii and its epidemiological survey by investigating the prevalence of its OXA genotypes in our hospital. Methods The OXA genetypes of 68 imipenem-resistant Acinetobacter baumannii strains isolated in our hospital from April 2010 to December 2010 were analyzed by multiplex PCR. Results Of the 68 isolated imipenem-resistant Acinetobacter baumannii strains, 7 were OXA-51 positive gene with a detection rate of 10.29%, 60 were OXA-51 and OXA-23 positive gene with a detection rate of 88.24%, and 1 was OXA-51 and OXA-58 positive gene with a detection rate of 1.47%. No OXA-24 gene was detected. Conclusion OXA-51+OXA-23 genotype is the popular OXA genetype of imipenem-resistant Acinetobacter baumannii in our hospital, indicating that it is the most important mechanism underlying the resistance of imipenem-resistant Acinetobacter baumannii to carbapenemases in our hospital, and laboratory should strengthen its monitoring of enzyme-producing strains.