CAJ | 학술논문

目的探索丙戊酸钠在动物模型中对利福平依赖性结核菌的抑制作用.方法分别以利福平依赖株、利福平耐药株及标准菌株感染BALB/c小鼠,以不同频率给予利福平及丙戊酸钠联合治疗6周,观察实验小鼠体征、肺脾病变程度,测定肺脾重量指数、肺组织荷菌量及结核菌利福平依赖性.结果依赖株感染的小鼠模型,利福平治疗组病变程度重,肺、脾称重均升高,肺组织荷菌量多;而利福平与丙戊酸钠联合治疗组可有效降低肺组织结核菌量.结论丙戊酸钠可显著抑制小鼠体内结核菌对利福平的依赖性.
목적탐색병무산납재동물모형중대리복평의뢰성결핵균적억제작용.방법분별이리복평의뢰주、리복평내약주급표준균주감염BALB/c소서,이불동빈솔급여리복평급병무산납연합치료6주,관찰실험소서체정、폐비병변정도,측정폐비중량지수、폐조직하균량급결핵균리복평의뢰성.결과의뢰주감염적소서모형,리복평치료조병변정도중,폐、비칭중균승고,폐조직하균량다;이리복평여병무산납연합치료조가유효강저폐조직결핵균량.결론병무산납가현저억제소서체내결핵균대리복평적의뢰성.
Objective To study the inhibitory effect of valproate (VPA) on rifampin-dependent tubercle bacilli. Methods BALB/c mice were infected with rifampin-dependent tubercle bacilli strains, rifampin-resistant tubercle bacilli strains and H37Rv, respectively. Six weeks after they were treated with combined rifampin and VPA, their physical signs were observed, and severity of lung and spleen lesions, lung and spleen weight indexes, tubercle bacilli strains load in lung tissues, and rifampin-dependent tubercle bacilli strains were detected. Results The lesions were severer, the lung and spleen weight indexes and the tubercle bacilli strains load in lung tissues were higher in rifampin-dependent tubercle bacilli strains infection mouse model and rifampin treatment group. Combined rifampin and VPA could effectively reduce the tubercle bacilli strains load in lung tissues of mice. Conclusion VPA can significantly inhibit rifampin-dependent tubercle bacilli in mice.