CAJ | 학술논문

目的观察帕瑞昔布钠用于脊柱侧凸矫形术后多模式镇痛的临床效果.方法50例脊柱侧凸患者随机分为帕瑞昔布钠组(P组)和对照组(C组).P组手术开始前30 min给予帕瑞昔布钠40 mg(氯化钠注射液稀释至2 ml)静脉注射,手术结束后48 h内,每12 h给予帕瑞昔布钠40 mg静脉注射.C组在相同时间给予等剂量的0.9%氯化钠注射液2 ml.P组和C组手术结束后均给予自控式镇痛泵(patient-controlled infusion analgesia,PCIA).术后2、6、12、24、48h分别对两组进行疼痛视觉模拟评分(VAS)及镇痛满意度评价,自控式镇痛泵(PCIA)按压次数、不良反应发生情况、凝血变化比较.结果术后P组6、12、24、48 h VAS评分,按压总次数和舒芬太尼使用量均低于C组,差异具有统计学意义(P<0.05).两组术后镇痛满意度差异有统计学意义.不良反应发生率、凝血功能变化差异无统计学意义.结论帕瑞昔布钠作为镇痛复合用药,可有效提高脊柱矫形术后的镇痛质量,节俭其他镇痛药物.
목적관찰파서석포납용우척주측철교형술후다모식진통적림상효과.방법50례척주측철환자수궤분위파서석포납조(P조)화대조조(C조).P조수술개시전30 min급여파서석포납40 mg(록화납주사액희석지2 ml)정맥주사,수술결속후48 h내,매12 h급여파서석포납40 mg정맥주사.C조재상동시간급여등제량적0.9%록화납주사액2 ml.P조화C조수술결속후균급여자공식진통빙(patient-controlled infusion analgesia,PCIA).술후2、6、12、24、48h분별대량조진행동통시각모의평분(VAS)급진통만의도평개,자공식진통빙(PCIA)안압차수、불량반응발생정황、응혈변화비교.결과술후P조6、12、24、48 h VAS평분,안압총차수화서분태니사용량균저우C조,차이구유통계학의의(P<0.05).량조술후진통만의도차이유통계학의의.불량반응발생솔、응혈공능변화차이무통계학의의.결론파서석포납작위진통복합용약,가유효제고척주교형술후적진통질량,절검기타진통약물.
Objective The to observe the clinical analgesic effect of parecoxib sodium in scoliosis patients after spine orthopedic surgery. Methods Fifty scoliosis patients were randomly divided into parecoxib sodium group and control group. Patients in parecoxib sodium group were given 40 mg parecoxib sodium diluted into 2 ml saline by intravenous injection for 30 minutes before operation followed by 40 mg every 12 hours within 48 hours after operation. Patients in control group were given the same volume of saline for the same time. Patients in two groups were given parecoxib sodium through the patient-controlled infusion analgesia pump (PCIAP) after operation. Visual analog pain was scored and analgesia satisfaction rate of patients was assessed at 2, 6, 12, 24 and 48 h after operation. Pumping times of PCIAP, adverse reactions and blood coagulation were compared. Results The score of visual analog pain, the pumping times of PCIAP, and the dosage of parecoxib sodium were lower while the analgesia satisfaction rate was significantly higher in parecoxib sodium group than in control group at 6, 12, 24, 48 h after operation (P < 0.05). No significant difference was found in adverse reactions and blood coagulation between the two groups. Conclusion Parecoxib sodium, as an analgesic, can improve the analgesic effect in scoliosis patients after spine orthopedic surgery, thus reducing the use of other analgesics.