CAJ | 학술논문

目的探讨模拟深埋条件下大鼠挤压伤解除挤压后心电的动态变化规律.方法 Wistar大鼠36只,经钳夹法作用于双后肢[压力为(4.5±0.3)kg],置入常压低氧舱内,舱内氧浓度为10%±0.1%,并禁食水.持续72 h后解除挤压,恢复常氧环境,自由进食水.随机分为挤压解除后即刻、1 d、3 d、7 d、14 d、28 d 6个时间点,行体表心电图检查.所有大鼠均于挤压前后做自身对照.结果挤压解除后1只大鼠于14 h死亡.其余各时间点80%大鼠(28/35)心电图发生明显异常变化,其中挤压解除后即刻时间点全部发生,包括ST段下移、T波高尖、心律失常、异常Q波、QRS波群增宽及QT间期延长;1~3 d出现ST段下移、T波高尖、心律失常;7 d可见ST段下移、T波高尖;14~28 d仍见50%大鼠ST段下移.结论模拟深埋条件下挤压伤复合低氧缺水缺食(三缺)大鼠于72 h解除挤压后心电图可发生明显异常,提示心脏是该复合性挤压伤的敏感靶器官.
목적탐토모의심매조건하대서제압상해제제압후심전적동태변화규률.방법 Wistar대서36지,경겸협법작용우쌍후지[압력위(4.5±0.3)kg],치입상압저양창내,창내양농도위10%±0.1%,병금식수.지속72 h후해제제압,회복상양배경,자유진식수.수궤분위제압해제후즉각、1 d、3 d、7 d、14 d、28 d 6개시간점,행체표심전도검사.소유대서균우제압전후주자신대조.결과제압해제후1지대서우14 h사망.기여각시간점80%대서(28/35)심전도발생명현이상변화,기중제압해제후즉각시간점전부발생,포괄ST단하이、T파고첨、심률실상、이상Q파、QRS파군증관급QT간기연장;1~3 d출현ST단하이、T파고첨、심률실상;7 d가견ST단하이、T파고첨;14~28 d잉견50%대서ST단하이.결론모의심매조건하제압상복합저양결수결식(삼결)대서우72 h해제제압후심전도가발생명현이상,제시심장시해복합성제압상적민감파기관.
Objective To study the changes on ECG after removal of crush in rats with crush injury in simulated deep buried condition. Methods Thirty-six Wistar rats were placed into an ordinary pressure hypoxic compartment with an oxygen concentration of 10%±0.1% without access to food or water after their hind limbs were clamped with a pressure of (4.5±0.3) kg. After the crush was consecutively removed for 72 hours, the rats were placed into an environment with a normal oxygen concentration with free access to food and water and underwent ECG on days 1, 3, 7, 14, and 28, respectively. Results Of the 35 rats with their crush removed, 1 rat died on 14 h, 28 had significant changes on their ECG, including ST-segment depression, tall peaked T-wave, QT prolongation, arrhythmias, abnormal Q wave on days 1-3, and ST-segment depression on days 14-28. Conclusion Significant changes can be found on ECG 72 hours after crush is removed in rats with crush injury in simulated deep buried condition, indicating that heart is a sensitive target organ for combined crush injury.